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Rosalind Lee

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Rosalind Lee
Rosalind Lee 2024
Alma materMassachusetts Institute of Technology
Known forDiscovery of microRNA
AwardsNewcomb Cleveland Prize (2003)
Scientific career
InstitutionsHarvard University
Dartmouth College
UMass Chan Medical School

Rosalind 'Candy' Lee is a biomedical scientist, best known for her breakthrough paper on the discovery of microRNA which was published in 1993.[1] In 2002, Lee was joint recipient of the Newcomb Cleveland Prize, for the best paper published in the journal Science that year.[2] In 2024, Lee's 1993 paper was cited as the seminal discovery for which the Nobel Prize in physiology or medicine was awarded that year, to co-author Victor Ambros, her husband.[3]

Career

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Lee graduated from Massachusetts Institute of Technology in 1976.[4] That same year, she married Victor Ambros, who was at that time a PhD student at MIT.[5]

Lee began working as a research assistant in Victor Ambros' lab in 1987. Her work on the cloning of lin-4 began in January, 1989, in Ambros's lab at Harvard University, and she was joined on the project in the fall of 1989 by Rhonda Feinbaum, a postdoc.[6][7] Lee and Feinbaum worked for a couple of years in a labor-intensive search for a gene behind a mutation.[8] What they eventually discovered was microRNA,[9] adding a new mechanism for gene regulation.[10][11] The 1993 paper was soon accepted for publication, and in a change of journal policy, it was published with a notice on the front page that it was jointly first-authored by Lee and Feinbaum,[6] clarifying that both contributed equally to the research.[12] In a 2004 paper, Lee, Feinbaum and Ambros describe how they eventually wrote up the work in 1993, and submitted it to the journal Cell, in parallel with a related paper by Gary Ruvkun.[6]

Lee's co-authored 1993 paper is widely regarded as the seminal contribution in the discovery of microRNA, for which her husband Ambros and Ruvkun were both awarded the Nobel Prize in 2024.[3] The Nobel announcement provoked interest into the question of why Lee hadn't also been recognized with the award.[12]

As of 2024, Lee is a Senior Scientist, in Program in Molecular Medicine, Dr. Victor Ambros's Molecular Medicine Laboratory, at UMass Chan Medical School.[13]

Awards

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References

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  1. ^ Lee, Rosalind C.; Feinbaum, Rhonda L.; Ambros, Victor (December 1993). "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14". Cell. 75 (5): 843–854. doi:10.1016/0092-8674(93)90529-Y. PMID 8252621.
  2. ^ "Dartmouth Medicine Magazine - Publications". dartmed.dartmouth.edu.
  3. ^ a b "The Nobel Prize in Physiology or Medicine 2024". NobelPrize.org.
  4. ^ "Donors Help to Build STEM Opportunities for Young People". MIT for a Better World.
  5. ^ "Dr. Paul Janssen Award". Dr. Paul Janssen Award.
  6. ^ a b c Lee, Rosalind; Feinbaum, Rhonda; Ambros, Victor (January 2004). "A short history of a short RNA". Cell. 116 (2 Suppl): S89–S92. doi:10.1016/S0092-8674(04)00035-2. PMID 15055592.
  7. ^ Sedwick, Caitlin (May 13, 2013). "Victor Ambros: The broad scope of microRNAs". Journal of Cell Biology. 201 (4): 492–493. doi:10.1083/jcb.2014pi. PMC 3653358. PMID 23671307.
  8. ^ Gitschier, Jane (March 5, 2010). "In the Tradition of Science: An Interview with Victor Ambrose". PLOS Genetics. 6 (3): e1000853. doi:10.1371/journal.pgen.1000853. PMC 2832673. PMID 20221254.
  9. ^ "Podcast: Victor Ambros on team effort behind Nobel Prize winning discovery of microRNA". UMass Chan Medical School. October 18, 2024. Retrieved October 20, 2024.
  10. ^ Ambros, Victor (October 17, 2024). "MicroRNA − a new Nobel laureate describes the scientific process of discovering these tiny molecules that turn genes on and off". Lusk Herald. Retrieved October 18, 2024.
  11. ^ "Victor Ambros '75, PhD '79 and Gary Ruvkun share Nobel Prize in Physiology or Medicine". MIT News. Massachusetts Institute of Technology. October 7, 2024. Retrieved October 18, 2024.
  12. ^ a b Domínguez, Nuño (October 8, 2024). "Why researcher Rosalind Lee, the wife of the Nobel Prize winner in Medicine, didn't receive the award as well?". EL PAÍS English.
  13. ^ "Senior Scientist". Dr. Ambros ' s Laboratory Homepage. November 19, 2024.
  14. ^ Lee, Rosalind C.; Ambros, Victor (October 26, 2001). "An Extensive Class of Small RNAs in Caenorhabditis elegans". Science. 294 (5543): 862–864. doi:10.1126/science.1065329. PMID 11679672 – via CrossRef.