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Rosalind Kornfeld

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Rosalind Kornfeld
Born
Rosalind Hauk

1935
DiedAugust 10, 2007[1]
Alma materWashington University
Scientific career
ThesisThe purification and properties of uridine diphosphate glucose-glycogen transglucosylase from rabbit muscle (1961)
Doctoral advisorDavid H. Brown

Rosalind Hauk Kornfeld (1935–2007) was a scientist at Washington University in St. Louis known for her research determining the structure and formation of oligosaccharides. The Society of Glycobiology annually awards a lifetime achievement award in her honor.

Education and career

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Rosalind Kornfeld née Hauk was born in Dallas, Texas and then grew up in Chevy Chase, Maryland. She earned a bachelor of science degree from George Washington University in 1957.[2] She went on to receive her Ph.D. degree in 1961 working on enzymes in rabbit muscles.[3] For a brief period she stayed at George Washington University as a postdoctoral investigator before moving to the National Institutes of Health as a fellow working with Victor Ginsburg. She moved back to St. Louis in 1965 when she accepted a position at Washington University in St. Louis.[2] She started as a research instructor, was promoted to research assistant professor in 1971, and then research associate professor in 1978. In 1981 she was named a professor of medicine and professor of biochemistry and molecular biophysics.[4] Kornfeld retired in 2001.[2]

Kornfeld founded the Academic Women's Network at Washington University and then served as its first president.[4][5] She also served as president of the Society of Glycobiology in 1993.[6]

Research

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Kornfeld's research laid the groundwork for the field of glycobiology with her investigations into nucleotide sugar biosynthesis and glycan ligands for lectins.[1] Korneld's notable accomplishments include defining the structure and function of N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, commonly known as the 'uncovering enzyme' or UCE.[7][8][9] She then worked to place that enzyme within the trans Golgi network.[8][10] Kornfeld wrote two influential reviews on oligosaccharides,[11][12] the second of which has been cited over 6000 times as of 2021.[13]

Selected publications

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  • Kornfeld, S.; Kornfeld, R.; Neufeld, E. F.; O'Brien, P. J. (1964-08-01). "The Feedback Control of Sugar Nucleotide Biosynthesis in Liver". Proceedings of the National Academy of Sciences. 52 (2): 371–379. Bibcode:1964PNAS...52..371K. doi:10.1073/pnas.52.2.371. ISSN 0027-8424. PMC 300286. PMID 14206604.
  • Kornfeld, R; Kornfeld, S (1976). "Comparative Aspects of Glycoprotein Structure". Annual Review of Biochemistry. 45 (1): 217–238. doi:10.1146/annurev.bi.45.070176.001245. ISSN 0066-4154. PMID 786150.
  • Kornfeld, Rosalind; Kornfeld, Stuart (1980). "Structure of Glycoproteins and Their Oligosaccharide Units". In Lennarz, William J. (ed.). The Biochemistry of Glycoproteins and Proteoglycans. Boston, MA: Springer US. ISBN 978-1-4684-1006-8. OCLC 840287599.
  • Kornfeld, K.; Reitman, M.L.; Kornfeld, R. (1981). "The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant". Journal of Biological Chemistry. 256 (13): 6633–6640. doi:10.1016/s0021-9258(19)69037-x. ISSN 0021-9258. PMID 7240233.
  • Kornfeld, Rosalind; Kornfeld, Stuart (1985). "Assembly of Asparagine-Linked Oligosaccharides". Annual Review of Biochemistry. 54 (1): 631–664. doi:10.1146/annurev.bi.54.070185.003215. ISSN 0066-4154. PMID 3896128.

Awards and honors

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Starting in 2007, the Academic Women's Network at Washington University has awarded the Rosalind Kornfeld Lecture for Distinguished Women in Science.[5] Since 2008, the Society for Glycobiology has awarded the Rosalind Kornfeld Lifetime Achievement Award to honor accomplishments in research within the field.[14] The second edition of Essentials in Glycobiology is dedicated to Rosalind Kornfeld and Roger W. Jeanloz, who are noted as "pioneers in the elucidation of glycan structure and function".[15]

Personal life

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Her husband was Stuart Kornfeld whom she met when she was a first year graduate student in biochemistry in 1958. They married in 1959 and worked together for 48 years; during his speech accepting the 2010 George M. Kober medal he acknowledged[16] the key role she played in their joint accomplishments, a situation that has been noted by others.[17][2][8] Her son, Kerry Kornfeld, is also a scientist and while he was in high school,[17] they jointly published a paper on lectins.[18]

References

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  1. ^ a b Ajit, V. (2007-09-13). "Obituary: Rosalind Hauk Kornfeld (1935 2007)". Glycobiology. 17 (11): 1148–1149. doi:10.1093/glycob/cwm102. ISSN 0959-6658.
  2. ^ a b c d Exton, John H. (2013-05-23). Crucible of Science: The Story of the Cori Laboratory. OUP USA. p. 161. ISBN 978-0-19-986107-1.
  3. ^ Kornfeld, Rosalind Hauk (1961). The purification and properties of uridine diphosphate glucose-glycogen transglucosylase from rabbit muscle (Thesis). OCLC 26083767.
  4. ^ a b "Rosalind Hauk Kornfeld - We've Come a Long Way, Maybe". beckerexhibits.wustl.edu. Retrieved 2021-11-05.
  5. ^ a b "Leadership Awards | Rosalind Kornfeld Leadership Award". 2013-11-06. Archived from the original on 2013-11-06. Retrieved 2021-11-05.
  6. ^ "Officers". www.glycobiology.org. Retrieved 2021-11-05.
  7. ^ Kornfeld R, Bao M, Brewer K, Noll C, Canfield W (Jan 2000). "Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase". J Biol Chem. 274 (46): 32778–85. doi:10.1074/jbc.274.46.32778. PMID 10551838.
  8. ^ a b c Kornfeld, Stuart (2018-06-20). "A Lifetime of Adventures in Glycobiology". Annual Review of Biochemistry. 87 (1): 1–21. doi:10.1146/annurev-biochem-062917-011911. ISSN 0066-4154. PMID 29925256. S2CID 49341010.
  9. ^ Kornfeld, Rosalind; Bao, Ming; Brewer, Kevin; Noll, Carolyn; Canfield, William M. (1998-09-04). "Purification and Multimeric Structure of BovineN-Acetylglucosamine-1-phosphodiester α-N-Acetylglucosaminidase *". Journal of Biological Chemistry. 273 (36): 23203–23210. doi:10.1074/jbc.273.36.23203. ISSN 0021-9258. PMID 9722550.
  10. ^ Rohrer, Jack; Kornfeld, Rosalind (2001). Pfeffer, Suzanne R. (ed.). "Lysosomal Hydrolase Mannose 6-Phosphate Uncovering Enzyme Resides in the trans -Golgi Network". Molecular Biology of the Cell. 12 (6): 1623–1631. doi:10.1091/mbc.12.6.1623. ISSN 1059-1524. PMC 37329. PMID 11408573.
  11. ^ Kornfeld, R; Kornfeld, S (1976). "Comparative Aspects of Glycoprotein Structure". Annual Review of Biochemistry. 45 (1): 217–238. doi:10.1146/annurev.bi.45.070176.001245. ISSN 0066-4154. PMID 786150.
  12. ^ Kornfeld, Rosalind; Kornfeld, Stuart (1985). "Assembly of Asparagine-Linked Oligosaccharides". Annual Review of Biochemistry. 54 (1): 631–664. doi:10.1146/annurev.bi.54.070185.003215. ISSN 0066-4154. PMID 3896128.
  13. ^ "Google Scholar". scholar.google.com. Retrieved 2021-11-05.
  14. ^ "Rosalind Kornfeld Award". www.glycobiology.org. Retrieved 2021-11-05.
  15. ^ Essentials of glycobiology. Ajit Varki (2nd ed.). Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press. 2009. ISBN 978-0-87969-770-9. OCLC 195765240.{{cite book}}: CS1 maint: others (link)
  16. ^ Kornfeld, Stuart (2010-07-01). "Acceptance of the 2010 George M. Kober Medal". The Journal of Clinical Investigation. 120 (7): 2639–2640. doi:10.1172/JCI43805. ISSN 0021-9738. PMC 2898622. PMID 20592477.
  17. ^ a b Varki, Ajit (2010-07-01). "2010 Association of American Physicians George M. Kober MedalIntroduction of Stuart Kornfeld". The Journal of Clinical Investigation. 120 (7): 2635–2638. doi:10.1172/JCI43804. ISSN 0021-9738. PMC 2898621. PMID 20592476.
  18. ^ Kornfeld, K.; Reitman, M.L.; Kornfeld, R. (1981). "The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant". Journal of Biological Chemistry. 256 (13): 6633–6640. doi:10.1016/S0021-9258(19)69037-X. PMID 7240233.
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