Sir Ronald Aylmer FisherFRS[5] (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic.[6][7] For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science"[8][9] and "the single most important figure in 20th century statistics".[10] In genetics, Fisher was the one to most comprehensively combine the ideas of Gregor Mendel and Charles Darwin,[11] as his work used mathematics to combine Mendelian genetics and natural selection; this contributed to the revival of Darwinism in the early 20th-century revision of the theory of evolution known as the modern synthesis. For his contributions to biology, Richard Dawkins declared Fisher to be the greatest of Darwin's successors.[12] He is also considered one of the founding fathers of Neo-Darwinism.[13][14] According to statistician Jeffrey T. Leek, Fisher is the most influential scientist of all time based off the number of citations of his contributions.[15]
Fisher has also been praised as a pioneer of the Information Age.[31] His work on a mathematical theory of information ran parallel to the work of Claude Shannon and Norbert Wiener, though based on statistical theory.[32][33][34] A concept to have come out of his work is that of Fisher information.[35] He also had ideas about social sciences,[14] which have been described as a "foundation for evolutionary social sciences".[36]
Fisher was born in East Finchley in London, England, into a middle-class household; his father, George, was a successful partner in Robinson & Fisher, auctioneers and fine art dealers.[38] He was one of twins, with the other twin being still-born[39] and grew up the youngest, with three sisters and one brother.[40] From 1896 until 1904 they lived at Inverforth House in London, where English Heritage installed a blue plaque in 2002, before moving to Streatham.[41] His mother, Kate, died from acute peritonitis when he was 14, and his father lost his business 18 months later.[38]
During 1913–1919, Fisher worked as a statistician in the City of London and taught physics and maths at a sequence of public schools, at the Thames Nautical Training College, and at Bradfield College. There he settled with his new bride, Eileen Guinness, with whom he had two sons and six daughters.[45]
In 1919, he began working at the Rothamsted Experimental Station in Hertfordshire, where he would remain for 14 years.[16] He had been offered a position at the Galton Laboratory in University College London led by Karl Pearson, but instead accepted a temporary role at Rothamsted to investigate the possibility of analysing the vast amount of crop data accumulated since 1842 from the "Classical Field Experiments". He analysed the data recorded over many years, and in 1921 published Studies in Crop Variation I, his first application of the analysis of variance (ANOVA).[50]Studies in Crop Variation II written with his first assistant, Winifred Mackenzie, became the model for later ANOVA work.[51] Later assistants who mastered and propagated Fisher's methods were Joseph Oscar Irwin, John Wishart and Frank Yates. Between 1912 and 1922 Fisher recommended, analysed (with heuristic proofs) and vastly popularized the maximum likelihood estimation method.[52]
On graduating from Cambridge University, 1912The peacock tail in flight, the classic example of a Fisherian runawayRothamsted Research
In 1925 he published Statistical Methods for Research Workers, one of the 20th century's most influential books on statistical methods.[53]Fisher's method[54][55] is a technique for data fusion or "meta-analysis" (analysis of analyses). Fisher formalized and popularized use of the p-value in statistics, which plays a central role in his approach. Fisher proposes the level p=0.05, or a 1 in 20 chance of being exceeded by chance, as a limit for statistical significance, and applies this to a normal distribution (as a two-tailed test), yielding the rule of two standard deviations (on a normal distribution) for statistical significance.[56] The significance of 1.96, the approximate value of the 97.5 percentile point of the normal distribution used in probability and statistics, also originated in this book.
"The value for which P = 0.05, or 1 in 20, is 1.96 or nearly 2; it is convenient to take this point as a limit in judging whether a deviation is to be considered significant or not."[57]
In Table 1 of the work, he gave the more precise value 1.959964.[58]
In 1928, Fisher was the first to use diffusion equations to attempt to calculate the distribution of allele frequencies and the estimation of genetic linkage by maximum likelihood methods among populations.[59]
One of Fisher's favourite aphorisms was "Natural selection is a mechanism for generating an exceedingly high degree of improbability."[62]
Fisher's fame grew, and he began to travel and lecture widely. In 1931, he spent six weeks at the Statistical Laboratory at Iowa State College where he gave three lectures per week, and met many American statisticians, including George W. Snedecor. He returned there again in 1936.[citation needed]
In 1935, he published The Design of Experiments, which was "also fundamental, [and promoted] statistical technique and application... The mathematical justification of the methods was not stressed and proofs were often barely sketched or omitted altogether .... [This] led H.B. Mann to fill the gaps with a rigorous mathematical treatment".[53][64]
In this book Fisher also outlined the Lady tasting tea, now a famous design of a statistical randomized experiment which uses Fisher's exact test and is the original exposition of Fisher's notion of a null hypothesis.[65][66]
In his 1937 paper The wave of advance of advantageous genes he proposed Fisher's equation in the context of population dynamics to describe the spatial spread of an advantageous allele, and explored its travelling wave solutions.[70] Out of this also came the Fisher–Kolmogorov equation.[71]
In 1937, he visited the Indian Statistical Institute in Calcutta, and its one part-time employee, P. C. Mahalanobis, often returning to encourage its development. He was the guest of honour at its 25th anniversary in 1957, when it had 2000 employees.[72]
In 1938, Fisher and Frank Yates described the Fisher–Yates shuffle in their book Statistical tables for biological, agricultural and medical research.[73] Their description of the algorithm used pencil and paper; a table of random numbers provided the randomness.
In 1936, Fisher used a Pearson's chi-squared test to analyze Mendel's data and concluded that Mendel's results were far too perfect, suggesting that adjustments (intentional or unconscious) had been made to the data to make the observations fit the hypothesis.[77] Later authors have claimed Fisher's analysis was flawed, proposing various statistical and botanical explanations for Mendel's numbers.[78][79] In 1947, Fisher co-founded the journal Heredity with Cyril Darlington and in 1949 he published The Theory of Inbreeding.
In 1950, he published "Gene Frequencies in a Cline Determined by Selection and Diffusion".[80] He developed computational algorithms for analyzing data from his balanced experimental designs,[81] with various editions and translations, becoming a standard reference work for scientists in many disciplines. In ecological genetics he and E. B. Ford showed that the force of natural selection was much stronger than had been assumed, with many ecogenetic situations (such as polymorphism) being maintained by the force of selection.
During this time he also worked on mouse chromosome mapping, breeding the mice in laboratories in his own house.[82]
Fisher publicly spoke out against the 1950 study showing that smoking tobacco causes lung cancer, arguing that correlation does not imply causation.[83][84][85][86][87][88] To quote his biographers Yates and Mather, "It has been suggested that the fact that Fisher was employed as consultant by the tobacco firms in this controversy casts doubt on the value of his arguments. This is to misjudge the man. He was not above accepting financial reward for his labours, but the reason for his interest was undoubtedly his dislike and mistrust of puritanical tendencies of all kinds; and perhaps also the personal solace he had always found in tobacco."[5] Others have suggested that his analysis was biased by professional conflicts and his own love of smoking;[89] he was a heavy pipe smoker.[90]
In the winter of 1954–1955 Fisher met Debabrata Basu, the Indian statistician who wrote in 1988, "With his reference set argument, Sir Ronald was trying to find a via media between the two poles of Statistics – Berkeley and Bayes.[92] My efforts to understand this Fisher compromise led me to the likelihood principle".[93]
Stained glass window (now removed) in the dining hall of Caius College, in Cambridge, commemorating Ronald Fisher and representing a Latin square, discussed by him in The Design of ExperimentsFisherian runaway, explaining how the desire for a phenotypic trait in one sex combined with the trait in the other sex (for example a peacock's tail) creates a runaway evolutionary extremizing of the trait.
Sexy son hypothesis, which hypothesizes that females may choose arbitrarily attractive male mates simply because they are attractive, thus increasing the attractiveness of their sons who attract more mates of their own. This is in contrast to theories of female mate choice based on the assumption that females choose attractive males because the attractive traits are markers of male viability.[102]
Mimicry, a similarity of one species to another that protects one or both.
Demonstrating that the probability of a mutation increasing the fitness of an organism decreases proportionately with the magnitude of the mutation and that larger populations carry more variation so that they have a greater chance of survival.
Fisher information, see also scoring algorithm also known as Fisher's scoring, and Minimum Fisher information, a variational principle which, when applied with the proper constraints needed to reproduce empirically known expectation values, determines the best probability distribution that characterizes the system.[106]
F-distribution, arises frequently as the null distribution of a test statistic, most notably in the analysis of variance
Inverse probability, a term Fisher used in 1922, referring to "the fundamental paradox of inverse probability" as the source of the confusion between statistical terms which refer to the true value to be estimated, with the actual value arrived at by estimation, which is subject to error.[108]
Sufficient statistic, when a statistic is sufficient with respect to a statistical model and its associated unknown parameter if "no other statistic that can be calculated from the same sample provides any additional information as to the value of the parameter".[110]
Fisher married Eileen Guinness, with whom he had two sons and six daughters.[45]
His marriage disintegrated during World War II, and his older son George, an aviator, was killed in combat.[113] His daughter Joan, who wrote a biography of her father, married the statistician George E. P. Box.[114]
According to Yates and Mather, "His large family, in particular, reared in conditions of great financial stringency, was a personal expression of his genetic and evolutionary convictions."[5] Fisher was noted for being loyal, and was seen as a patriot, a member of the Church of England, politically conservative, as well as a scientific rationalist. He developed a reputation for carelessness in his dress and was the archetype of the absent-minded professor. H. Allen Orr describes him in the Boston Review as a "deeply devout Anglican who, between founding modern statistics and population genetics, penned articles for church magazines".[115] In a 1955 broadcast on Science and Christianity,[5] he said:
The custom of making abstract dogmatic assertions is not, certainly, derived from the teaching of Jesus, but has been a widespread weakness among religious teachers in subsequent centuries. I do not think that the word for the Christian virtue of faith should be prostituted to mean the credulous acceptance of all such piously intended assertions. Much self-deception in the young believer is needed to convince himself that he knows that of which in reality he knows himself to be ignorant. That surely is hypocrisy, against which we have been most conspicuously warned.
Between 1950 and 1951, Fisher, along with other leading geneticists and anthropologists of his time, was asked to comment on a statement that UNESCO was preparing on the nature of race and racial differences, which was published in 1950 as the UNESCO Statement on Race. The statement, along with the comments and criticisms of a large number of scientists including Fisher, is published in "The Race Concept: Results of an Inquiry" (1952).[118]
Fisher was one of four scientists who opposed the statement. In his own words, Fisher's opposition is based on "one fundamental objection to the Statement", which "destroys the very spirit of the whole document." He believes that human groups differ profoundly "in their innate capacity for intellectual and emotional development" and concludes from this that the "practical international problem is that of learning to share the resources of this planet amicably with persons of materially different nature, and that this problem is being obscured by entirely well-intentioned efforts to minimize the real differences that exist."[119][120][121]
Fisher's opinions are clarified by his more detailed comments on Section 5 of the statement, which are concerned with psychological and mental differences between the races. Section 5 concludes as follows:
Scientifically, however, we realized that any common psychological attribute is more likely to be due to a common historical and social background, and that such attributes may obscure the fact that, within different populations consisting of many human types, one will find approximately the same range of temperament and intelligence.[118]: 14
Of the entire statement, Section 5 recorded the most dissenting viewpoints. It was recorded that "Fisher's attitude … is the same as Muller's and Sturtevant's".[118]: 56 Muller's criticism was recorded in more detail and was noted to "represent an important trend of ideas":
I quite agree with the chief intention of the article as a whole, which, I take it, is to bring out the relative unimportance of such genetic mental differences between races as may exist, in contrast to the importance of the mental differences (between individuals as well as between nations) caused by tradition, training and other aspects of the environment. However, in view of the admitted existence of some physically expressed hereditary differences of a conspicuous nature, between the averages or the medians of the races, it would be strange if there were not also some hereditary differences affecting the mental characteristics which develop in a given environment, between these averages or medians. At the same time, these mental differences might usually be unimportant in comparison with those between individuals of the same race…. To the great majority of geneticists it seems absurd to suppose that psychological characteristics are subject to entirely different laws of heredity or development than other biological characteristics. Even though the former characteristics are far more influenced than the latter by environment, in the form of past experiences, they must have a highly complex genetic basis.[118]: 52
Fisher's own words were quoted as follows:
As you ask for remarks and suggestions, there is one that occurs to me, unfortunately of a somewhat fundamental nature, namely that the Statement as it stands appears to draw a distinction between the body and mind of men, which must, I think, prove untenable. It appears to me unmistakable that gene differences which influence the growth or physiological development of an organism will ordinarily pari passu influence the congenital inclinations and capacities of the mind. In fact, I should say that, to vary conclusion (2) on page 5, 'Available scientific knowledge provides a firm basis for believing that the groups of mankind differ in their innate capacity for intellectual and emotional development,' seeing that such groups do differ undoubtedly in a very large number of their genes.[118]: 56
Fisher also ended a 1954 letter to Reginald Ruggles Gates, a Canadian-born geneticist who argued that different racial groups were different species, with the words:
I am sorry that there should be propaganda in favour of miscegenation in North America as I am sure it can do nothing but harm. Is it beyond human endeavour to give and justly administer equal rights to all citizens without fooling ourselves that these are equivalent items?[122]
Fisher's writings nearly all discuss human populations or humanity as a whole without reference to race or specific racial groups, and none of his work explicitly supports the idea of racial superiority or white supremacy.[122] Fisher had a close personal relationship with Indian statistician P.C. Mahalanobis, and significantly contributed to the development of the Indian Statistical Institute; and Fisher's graduate students included Walter Bodmer, a child of Jewish-German parents who fled from Nazi Germany while he was young, and Ebenezer Laing, an African geneticist from Ghana.[122]Daniel Kevles, an American historian of science, described Fisher as an "anti-racist conservative".[122] However, British historian Robert J. Evans, writing in The New Statesman, argued that Fisher's views on eugenics and his opposition to UNESCO's statement about genetic racial differences were indicative of racism.[123]
In 1911, Fisher became founding Chairman of the University of Cambridge Eugenics Society, whose other founding members included John Maynard Keynes, R. C. Punnett, and Horace Darwin. After members of the Cambridge Society – including Fisher – stewarded the First International Eugenics Congress in London in summer 1912, a link was forged with the Eugenics Society (UK).[124] He saw eugenics as addressing pressing social and scientific issues that encompassed and drove his interest in both genetics and statistics. During World War I Fisher started writing book reviews for The Eugenics Review and volunteered to undertake all such reviews for the journal, being hired for a part-time position.
The last third of The Genetical Theory of Natural Selection focused on eugenics, attributing the fall of civilizations to the fertility of their upper classes being diminished, and used British 1911 census data to show an inverse relationship between fertility and social class, which was partly due, he claimed, to the lower financial costs and hence increasing social status of families with fewer children. He proposed the abolition of extra allowances to large families, with the allowances proportional to the earnings of the father.[125][126][127] He served in several official committees to promote eugenics, including the Committee for Legalizing Eugenic Sterilization which drafted legislation aiming to limit the fertility of "feeble minded high-grade defectives ... comprising a tenth of the total population". It was proposed that this policy would allow for voluntary sterilisation. Fisher was against the idea of forced sterilisation.[128][129]
Beginning in 1934, Fisher became disillusioned with the Eugenics Society over concerns that its activities were increasingly aimed in a political rather than scientific direction; he formally dissociated with the Society in 1941.[122]
Fisher wrote a testimony on behalf of the eugenicist Otmar Freiherr von Verschuer. He wrote that, although the Nazis used Verschuer's work to give scientific support for their ideology, it was "[Verschuer's] misfortune rather than his fault that racial theory was a part of the Nazi ideology."[122][130] He conducted extensive correspondence with von Verschuer over decades, which is held at the University of Adelaide.[90]
In 2010, the R.A. Fisher Chair in Statistical Genetics was established in University College London to recognise Fisher's extraordinary contributions to both statistics and genetics.
Anders Hald called Fisher "a genius who almost single-handedly created the foundations for modern statistical science",[8] while Richard Dawkins named him "the greatest biologist since Darwin":
Not only was he the most original and constructive of the architects of the neo-Darwinian synthesis, Fisher also was the father of modern statistics and experimental design. He therefore could be said to have provided researchers in biology and medicine with their most important research tools, as well as with the modern version of biology's central theorem.[137]
To biologists, he was an architect of the "modern synthesis" that used mathematical models to integrate Mendelian genetics with Darwin's selection theories. To psychologists, Fisher was the inventor of various statistical tests that are still supposed to be used whenever possible in psychology journals. To farmers, Fisher was the founder of experimental agricultural research, saving millions from starvation through rational crop breeding programs.[138]
Fisher and Sewall Wright both contributed to the development of population genetics, which became part of the modern synthesis. The interpretation of the mathematical theories of population genetics became a bone of contention between Fisher and Wright by the mid-1920s, and the issue became acrimonious. Dispute persisted for the rest of Fisher's life.[139] A 2021 paper, authored by trustees of the "Fisher Memorial Trust", commented that recent criticism of Fisher could mostly be characterised as "reconsideration of the honour given to individuals from preceding times who are felt to have contributed to social injustice in the past, or to have held views that are felt to have promoted social injustice."[122]
^Owen, A. R. G. (1962). "An appreciation for the Life and Work of Sir Ronald Aylmer Fisher". The Statistician. 12 (4): 313. doi:10.2307/2986951. JSTOR2986951.
^ abEsposito, Maurizio (July 2016). "From human science to biology: The second synthesis of Ronald Fisher". History of the Human Sciences. 29 (3): 44–62. doi:10.1177/0952695116653866. S2CID147742674.
^Charlesworth, Brian (2017), "Fisher", in Vonk, Jennifer; Shackelford, Todd (eds.), Encyclopedia of Animal Cognition and Behavior, Cham: Springer International Publishing, pp. 1–4, doi:10.1007/978-3-319-47829-6_440-1, ISBN978-3-319-47829-6, retrieved 20 June 2024
^Fisher, Ronald A. (1921). ") Studies in Crop Variation. I. An Examination of the Yield of Dressed Grain from Broadbalk". Journal of Agricultural Science. 11 (2): 107–135. doi:10.1017/S0021859600003750. hdl:2440/15170. S2CID86029217.
^Fisher, Ronald A. (1923). ") Studies in Crop Variation. II. The Manurial Response of Different Potato Varieties". Journal of Agricultural Science. 13 (3): 311–320. doi:10.1017/S0021859600003592. hdl:2440/15179. S2CID85985907.
^Pfanzagl, Johann; Hamböker, R. (1994). Parametric statistical theory. Berlin: Walter de Gruyter. pp. 207–208. ISBN978-3-11-013863-4.
^ abConniffe, Denis (1991). "R.A. Fisher and the development of statistics - a view in his centerary year". Journal of the Statistical and Social Inquiry Society of Ireland. 26 (3): 55–108. hdl:2262/2764. ProQuest911976618.
^The Genetical Theory of Natural Selection. It was first reported in 1936 by Julian Huxley and often repeated in Huxley's work (e.g., 1942, 1954) until it finally passed into the language unattributed through the writings of C. H. Waddington, Gavin de Beer, Ernst Mayr, and Richard Dawkins.
^Mann, H.B. (1949). Analysis and design of experiments: Analysis of variance and analysis of variance designs. New York: Dover. MR0032177.
^Fisher, R. A. (1971) The Design of Experiments. Chapter II. The Principles of Experimentation, Illustrated by a Psycho-physical Experiment, Section 8. The Null Hypothesis
^OED quote: 1935 R. A. Fisher, The Design of Experiments ii. 19, "We may speak of this hypothesis as the 'null hypothesis'...the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation."
^Fisher, R. A.; Corbet, A. S.; Williams, C. B. (1943). "The relation between the number of species and the number of individuals in a random sample of an animal population". Journal of Animal Ecology. 12 (1): 42–58. Bibcode:1943JAnEc..12...42F. doi:10.2307/1411. JSTOR1411.
^Franklin, Allan; Edwards, A. W. F.; Fairbanks, Daniel J.; Hartl, Daniel L.; Seidenfeld, Teddy (2008). Ending the Mendel-Fisher Controversy. University of Pittsburgh Press. ISBN978-0822973409.
^The term "Berkeley" has several meanings, here. Basu refers to the leadership of Jerzy Neyman's department of statistics at the University of California at Berkeley in the world of frequentist statistics. Secondly, Basu alludes to the British philosopher George Berkeley who criticized the use of infinitesimals in mathematical analysis; Berkeley's criticisms were answered by Thomas Bayes in a pamphlet.
^Clutton-Brock, T.H. (1991). The Evolution of Parental Care. Princeton, NJ: Princeton U. Press. p. 9.
^Trivers, R.L. (1972), "Parental investment and sexual selection", in Campbell, B. (ed.), Sexual selection and the descent of man 1871–1971, Chicago, IL: Aldine, pp. 136–179, ISBN978-0-435-62157-5
^Walpole, Ronald; Myers, Raymond; Myers, Sharon; Ye, Keying (2002). Probability and Statistics for Engineers and Scientists (7th ed.). Pearson Education. p. 237. ISBN978-81-7758-404-2.
^"(Research with Ronald Fisher)". Journal of the Society for Psychical Research. 44 (738). Society for Psychical Research: 392. 1967. The targets (one-figure numbers and letters of the alphabet) were pasted on the backs of visiting cards, which were put into random order either by shuffling or by the use of random number tables loaned us by Professor Sir Ronald Fisher.
^Norton, Bernard (27 April 1978). "A 'fashionable fallacy' defended". New Scientist. Fisher worked as he did because he was an ardent eugenist. (original italics) ... Careful study of Fisher's writings, moreover, enables one to establish strong connections between the problems that Fisher faced qua eugenist and the work in genetics outlined above.
^Blacker, C.P. (1931). "The sterilization proposals: A history of their development". Eugen Rev. 22 (4): 240. PMC2984995. PMID21259955. Amemorandum was accordingly circulated to the Council signed by Dr. R.A. Fisher, Professor Huxley, Dr. J.A. Ryle, Mr. E.J. Lidbetter, and myself, asking for authorization to form a sub-committee, the aim of which would be to secure the legalization of eugenics sterilization. The memorandum was unanimously approved by the Council, and in this way the nucleus of the existing Committee for Legalizing Eugenic Sterilization was formed.
^Weiss, Sheila Faith (2010). "After the Fall: Political Whitewashing, Professional Posturing, and Personal Refashioning in the Postwar Career of Otmar Freiherr von Verschuer". Isis. 101 (4): 745. doi:10.1086/657474. JSTOR10.1086/657474. PMID21409983. S2CID28148032.
^"Ronald Aymler Fisher". American Academy of Arts & Sciences. 9 February 2023. Retrieved 27 April 2023.
^Fisher, R. A. (23 April 2024). "On a property connecting the χ2 measure of discrepancy with the method of maximum likelihood". Atti del Congresso Internazionale dei Matematici: Bologna del 3 al 10 de settembre di 1928. Vol. 6. pp. 95–100. hdl:2440/15197.
^Tommi Jaakkola and David Haussler (1998), Exploiting Generative Models in Discriminative Classifiers. In Advances in Neural Information Processing Systems 11, pages 487–493. MIT Press. ISBN978-0-262-11245-1PS, Citeseer
^Dawkins, Richard (2010). "Who is the Greatest Biologist Since Darwin? Why?". Who is the greatest biologist since Darwin? That's far less obvious, and no doubt many good candidates will be put forward. My own nominee would be Ronald Fisher. Not only was he the most original and constructive of the architects of the neo-Darwinian synthesis. Fisher also was the father of modern statistics and experimental design. He therefore could be said to have provided researchers in biology and medicine with their most important research tools, as well as with the modern version of biology's central theorem.
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