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Richard Lewisohn

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Richard Lewisohn
Born(1875-06-12)June 12, 1875
Hamburg, Germany
DiedAugust 11, 1961(1961-08-11) (aged 86)
New York City
Alma materUniversity of Freiburg
Known forUse of sodium citrate to prevent clotting in blood
Scientific career
FieldsSurgery
InstitutionsMount Sinai Hospital (Manhattan)

Richard Lewisohn (July 12, 1875 in Hamburg – August 11, 1961 in New York[1]) was a German-American surgeon. At Mount Sinai Hospital in Manhattan, he developed procedures that made blood transfusion practical.

Life and career

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Lewisohn was born to German-Jewish[2] parents in Hamburg and was educated at the local Gymnasium from where he entered medical school in Kiel in 1893.[3] As was typical for German medical students, he attended several different medical schools, before receiving his doctorate from the University of Freiburg in 1899 with a thesis on malignant kidney tumors.[3] He then served for two years as an assistant to Karl Weigert at the Senckenberg Institute in Frankfurt. In 1904 he became an assistant to Geheimrat Czerny in Heidelberg.[3] In 1906 he emigrated to New York, where he became a gastroenterologist and surgeon;[4] from 1928 to 1936 he was chief of the general surgical service at Mount Sinai.[5]

Scientific career

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Blood transfusion

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Following early speculation and its use in animal transfusion,[6] in April 1914 Belgian physician Albert Hustin used sodium citrate to prevent donated blood from clotting during transfusion.[1] Luis Agote had also used a citrate method at Buenos Aires on 14 November 1914.[1] Working independently, Lewisohn's contribution, in 1915, was to determine the optimal concentration of sodium citrate for preserving blood products without inducing toxicity (0.2% for transfusions not exceeding 5g).[7] Correct use of sodium citrate made it possible to preserve blood products for longer and longer periods of time allowing donor and donee to be geographically separate. His research was put into use during the First World War[7] though it was only introduced to British medical services in 1917 (by Oswald Robertson).[1]

Surgery

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In 1922, he convinced his colleague Albert Berg to perform the first subtotal gastrectomy for peptic ulcer in the United States.[5] He had traveled previously to Hans von Haberer in Innsbruck, Austria, where the method had already been applied and where he became familiar with the surgical techniques.[5] Following the successful application at Mount Sinai, the technique spread to the rest of the United States for ulcers resistant to other treatment.[3] Lewisohn was also a contemporary of Alexis Moschcowitz and his successor as chief of the general surgical service at Mount Sinai.[5]

In 1937, Lewisohn retired from active surgery and became a consulting surgeon. He focused his time on cancer research,[3] and was "the first to define the significance of folic acid in the biology of cancer" and was "among the first to use folic acid antagonists clinically".[5] He spent approximately ten years thus engaged, before retiring more completely, only to re-enter the world of medical research in 1954, to oversee and the creation of a new cell research laboratory at Mount Sinai, made possible by a large donation.[3]

Honours

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In 1955 he received the American Association of Blood Banks' Karl Landsteiner Memorial Award.[1] In January 1959 he became an honorary fellow of the Royal College of Surgeons of England, having been a fellow of the American College of Surgeons since 1916.[7] Lewisohn was also a Fellow of the American Gastroenterological Association, and served on the American Board of Surgery.[7]

Personal life

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In 1911, Lewisohn married Constance Strauss. They had three children, two of whom survived to adulthood. [3]

Selected works

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  • Lewisohn, Richard (1924). "The Citrate Method of Blood Transfusion after Ten Years; A Retrospect". The Boston Medical and Surgical Journal. 190 (18): 733–742. doi:10.1056/NEJM192405011901801. ISSN 0096-6762.
  • Lewisohn, Richard (1952). "Blood transfusion by the citrate method". The American Journal of Medicine. 13 (5): 550–555. doi:10.1016/0002-9343(52)90019-3. ISSN 0002-9343. PMID 12996530. (Reprinted from the original 1915 article.)

References

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  1. ^ a b c d e "Lewisohn, Richard". Plarr's Lives of the Fellows Online. Royal College of Surgeons of England. April 28, 2014. Retrieved March 5, 2016.
  2. ^ Schwartz SI. Contributions of jewish surgeons in the United States. Rambam Maimonides Med J. 2011;2(1):e0020. Published 2011 Jan 31. doi:10.5041/RMMJ.10020
  3. ^ a b c d e f g Klemperer, P.; Lewisohn, M. (February 1962). "Richard LEWISOHN, 1875-1961". Journal of the Mount Sinai Hospital, New York. 29: 1–4. ISSN 0099-9695. PMID 14037101.
  4. ^ Hedley-Whyte, John; Milamed, Debra R (September 2010). "Blood and War". The Ulster Medical Journal. 79 (3): 125–134. ISSN 0041-6193. PMC 3284718. PMID 22375087.
  5. ^ a b c d e Schwartz, Seymour (January 2011). "Contributions of Jewish surgeons in the United States". Rambam Maimonides Medical Journal. 2 (1): e0020. doi:10.5041/rmmj.10020. PMC 3678788. PMID 23908792. Retrieved March 5, 2016.
  6. ^ Mollison (January 2000). "The Introduction of Citrate as an Anticoagulant for Transfusion and of Glucose as a Red Cell Preservative". British Journal of Haematology. 108 (1): 13–18. doi:10.1046/j.1365-2141.2000.01827.x. ISSN 1365-2141. PMID 10651719. S2CID 29218159.
  7. ^ a b c d "In Memoriam: Richard Lewisohn, M.D., F.A.C.S., Hon. F.R.C.S". Annals of the Royal College of Surgeons of England. 30 (2): 130–131. February 1962. PMC 2414161.
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