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Ras p21 protein activator 2

From Wikipedia, the free encyclopedia
RASA2
Identifiers
AliasesRASA2, GAP1M, RAS p21 protein activator 2
External IDsOMIM: 601589; MGI: 2149960; HomoloGene: 4745; GeneCards: RASA2; OMA:RASA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303245
NM_001303246
NM_006506

NM_053268

RefSeq (protein)

NP_001290174
NP_001290175
NP_006497

NP_444498

Location (UCSC)Chr 3: 141.49 – 141.62 MbChr 9: 96.54 – 96.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. [5]

Function

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The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155903Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032413Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.