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Protein-coding gene in the species Homo sapiens
Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene .[ 5] [ 6]
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.[ 6]
RGS16 has been shown to interact with GNAQ [ 7] GNAI3 .[ 8] [ 9]
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"Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes" . Journal of Immunology . 162 (5): 2677– 82. doi :10.4049/jimmunol.162.5.2677 PMID 10072511 . Druey KM, Ugur O, Caron JM, Chen CK, Backlund PS, Jones TL (Jun 1999). "Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling" . The Journal of Biological Chemistry . 274 (26): 18836– 42. doi :10.1074/jbc.274.26.18836 PMID 10373502 . Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (Apr 2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner" . The Journal of Biological Chemistry . 286 (17): 15116– 25. doi :10.1074/jbc.M110.216234 PMC 3083217 PMID 21357625 . Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). 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