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RENBP

From Wikipedia, the free encyclopedia
RENBP
Identifiers
AliasesRENBP, RBP, RNBP, renin binding protein
External IDsOMIM: 312420; MGI: 105940; HomoloGene: 2184; GeneCards: RENBP; OMA:RENBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002910

NM_001164704
NM_023132

RefSeq (protein)

NP_002901

NP_001158176
NP_075621

Location (UCSC)Chr X: 153.94 – 153.94 MbChr X: 72.97 – 72.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.[5][6]

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102032Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031387Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem. 267 (18): 13007–13. doi:10.1016/S0021-9258(18)42374-5. PMID 1618798.
  6. ^ a b "Entrez Gene: RENBP renin binding protein".

Further reading

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