RELT

RELT
Identifiers
Aliases	RELT, TNFRSF19L, TRLT, RELT tumor necrosis factor receptor, TNF receptor, RELT TNF receptor, AI3C
External IDs	OMIM: 611211; MGI: 2443373; HomoloGene: 13151; GeneCards: RELT; OMA:RELT - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,397,474 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,512,653 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; bone marrow cells; ; spleen; ; gastrocnemius muscle; ; muscle of thigh; ; appendix; ; lymph node; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; bone marrow; ; quadriceps femoris muscle; ; spleen; ; muscle tissue; ; skeletal muscle tissue; ; islet of Langerhans; ; hypothalamus; ; female urethra; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; nucleus; perinuclear region of cytoplasm;
Biological process	multicellular organism development; regulation of apoptotic process; apoptotic signaling pathway; response to lipopolysaccharide; inflammatory response; regulation of cell population proliferation; immune response; tumor necrosis factor-mediated signaling pathway; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	84957
	320100
	ENSG00000054967
	ENSMUSG00000008318
	Q969Z4
	Q8BX43
	NM_032871; NM_152222
	NM_177073; NM_001358914
	NP_116260; NP_689408
	NP_796047; NP_001345843
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily member 19L is a protein that in humans is encoded by the RELT gene.^[5]^[6]^[7]^[8]^[9]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054967 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.
^ Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (May 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human" (PDF). J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.
^ Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
^ Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
^ ^a ^b "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054967 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313261-5] Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.

[pmid16547002-6] Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (May 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human" (PDF). J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.

[pmid16950202-7] Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.

[pmid16389068-8] Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.

[entrez-9] "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".

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