Povorcitinib

Povorcitinib
Clinical data
Other names	INCB-054707
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 4-[3-(cyanomethyl)-3-[4-(3,5-dimethyl-1H-pyrazol-4-yl)pyrazol-1-yl]azetidin-1-yl]-2,5-difluoro-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzamide;
CAS Number	1637677-22-5;
PubChem CID	86280672;
IUPHAR/BPS	11881;
DrugBank	DB18855;
ChemSpider	115010428;
UNII	N0JWC7RO00;
KEGG	D12575;
ChEMBL	ChEMBL5095079;
Chemical and physical data
Formula	C23H22F5N7O
Molar mass	507.469 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=NN1)C)C2=CN(N=C2)C3(CN(C3)C4=C(C=C(C(=C4)F)C(=O)N[C@@H](C)C(F)(F)F)F)CC#N;
	InChI InChI=1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1; Key:MSGYSFWCPOBHEV-AWEZNQCLSA-N;

Povorcitinib is an investigational new drug that is being evaluated for the treatment of the skin conditions hidradenitis suppurativa^[1]^[2] and chronic prurigo.^[3]^[4] It is a JAK1 inhibitor.^[5]

References

^ Alavi A, Hamzavi I, Brown K, Santos LL, Zhu Z, Liu H, Howell MD, Kirby JS. Janus kinase 1 inhibitor INCB054707 for patients with moderate-to-severe hidradenitis suppurativa: results from two phase II studies. Br J Dermatol. 2022 May;186(5):803-813. doi:10.1111/bjd.20969 PMID 34978076
^ Kirby JS, Okun MM, Alavi A, Bechara FG, Zouboulis CC, Brown K, Santos LL, Wang A, Bibeau KB, Kimball AB, Porter ML. Efficacy and safety of the oral Janus kinase 1 inhibitor povorcitinib (INCB054707) in patients with hidradenitis suppurativa in a phase 2, randomized, double-blind, dose-ranging, placebo-controlled study. J Am Acad Dermatol. 2024 Mar;90(3):521-529. doi:10.1016/j.jaad.2023.10.034 PMID 37871805
^ "Povorcitinib - Incyte Corporation". AdisInsight. Springer Nature Switzerland AG.
^ Thünemann J, Müller S, Steinbrink K, Ständer S, Zeidler C (June 2024). "Chronic Prurigo". Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG. 22 (6): 813–823. doi:10.1111/ddg.15317. PMID 38722190.
^ Liao V, Cornman HL, Ma E, Kwatra SG (May 2024). "Prurigo nodularis: new insights into pathogenesis and novel therapeutics". The British Journal of Dermatology. 190 (6): 798–810. doi:10.1093/bjd/ljae052. PMC 11099982. PMID 38345154.

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