Pleckstrin homology domain containing A4

PLEKHA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UPQ, 1UPR
Identifiers
Aliases	PLEKHA4, PEPP1, pleckstrin homology domain containing A4
External IDs	OMIM: 607769; MGI: 1916467; HomoloGene: 10848; GeneCards: PLEKHA4; OMA:PLEKHA4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,868,617 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,203,653 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; trigeminal ganglion; ; Descending thoracic aorta; ; spinal ganglia; ; apex of heart; ; right ovary; ; gastric mucosa; ; ascending aorta; ; left coronary artery; ; left ovary;
	Top expressed in
	sciatic nerve; ; fourth ventricle; ; choroid plexus of fourth ventricle; ; lumbar spinal ganglion; ; choroidal fissure; ; saccule; ; otic vesicle; ; cochlea; ; extraocular muscle; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding; phosphatidylinositol-3-phosphate binding;
Cellular component	cytoplasm; membrane; plasma membrane; cellular component;
Biological process	phosphatidylinositol biosynthetic process; biological process;
	Sources:Amigo / QuickGO
Orthologs
	57664
	69217
	ENSG00000105559
	ENSMUSG00000040428
	Q9H4M7
	Q8VC98
	NM_001161354; NM_020904
	NM_148927; NM_001381849
	NP_001154826; NP_065955
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene. ^[5]

Function

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105559 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040428 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Pleckstrin homology domain containing A4". Retrieved 2017-08-24.

Function

References

Further reading