Phosphatidylinositol transfer protein, alpha

PITPNA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UW5
Identifiers
Aliases	PITPNA, HEL-S-36, PI-TPalpha, PITPN, VIB1A, phosphatidylinositol transfer protein alpha
External IDs	OMIM: 600174; MGI: 99887; HomoloGene: 55958; GeneCards: PITPNA; OMA:PITPNA - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,562,792 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,519,630 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; parotid gland; ; Pons; ; lateral nuclear group of thalamus; ; skin of leg; ; skin of abdomen; ; monocyte; ; minor salivary glands; ; prefrontal cortex; ; mucosa of esophagus;
	Top expressed in
	retinal pigment epithelium; ; stroma of bone marrow; ; dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; superior frontal gyrus; ; medial vestibular nucleus; ; cerebellar cortex; ; granulocyte; ; ileum; ; jejunum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; phosphatidylcholine transporter activity; phosphatidylinositol transfer activity; phosphatidylcholine binding; phosphatidylinositol binding; phosphatidylglycerol binding; phospholipid transporter activity;
Cellular component	cytoplasm; myelin sheath; extracellular exosome; intracellular anatomical structure; cytosol;
Biological process	visual perception; lipid metabolism; axonogenesis; phospholipid transport; interleukin-12-mediated signaling pathway; transport;
	Sources:Amigo / QuickGO
Orthologs
	5306
	18738
	ENSG00000174238
	ENSMUSG00000017781
	Q00169
	P53810
	NM_006224
	NM_008850
	NP_006215
	NP_032876
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene.^[5]

Phosphatidylinositol transfer proteins are a diverse set of cytosolic phospholipid transfer proteins that are distinguished by their ability to transfer phospholipids between membranes in vitro (Wirtz, 1991).^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174238 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017781 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hay JC, Martin TF (Jan 1994). "Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca(2+)-activated secretion". Nature. 366 (6455): 572–5. doi:10.1038/366572a0. PMID 8255295. S2CID 4348488.
^ "Entrez Gene: PITPNA phosphatidylinositol transfer protein, alpha".

References

Further reading