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Phosducin family

From Wikipedia, the free encyclopedia
Phosducin (yellow) - Transducin beta-gamma complex
Identifiers
SymbolPhosducin
PfamPF02114
InterProIPR001200
SCOP21b9y / SCOPe / SUPFAM
OPM superfamily131
OPM protein1b9x
CDDcd02987
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The outer and inner segments of vertebrate retina rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the guanosine triphosphate-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A.[1] The protein is thought to participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Similar proteins have been isolated from the pineal gland and it is believed that the function of the protein is the same in both retina and pineal gland.[2]

Human proteins containing this domain

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Gene Aliases Protein
PDC MEKA phosducin
PDCL PhLP1 phosducin-like
PDCL2 GCPHLP phosducin-like 2
PDCL3 PhLP2A phosducin-like 3
TXNDC9 PhLP3 thioredoxin domain containing 9

References

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  1. ^ Craft CM, Lee RH, Fowler A, Lolley RN, McGinnis JF (1990). "Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells". J. Biol. Chem. 265 (26): 15867–15873. doi:10.1016/S0021-9258(18)55479-X. PMID 2203790.
  2. ^ Takagi T, Abe T, Nakabayashi H, Tamada H, Sakuragi S, Yamaki K, Shinohara T (1990). "Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland". Gene. 91 (2): 209–215. doi:10.1016/0378-1119(90)90090-E. PMID 2210381.
This article incorporates text from the public domain Pfam and InterPro: IPR001200