Perfluorohexyloctane
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| Clinical data | |
|---|---|
| Trade names | Miebo |
| Other names | NOV03; 1-(perfluorohexyl)octane |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a623054 |
| License data | |
| Routes of administration | Eye drops |
| ATC code |
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| Legal status | |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
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| Chemical and physical data | |
| Formula | C14H17F13 |
| Molar mass | 432.269 g·mol−1 |
| 3D model (JSmol) | |
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Perfluorohexyloctane, sold under the brand names EvoTears[3] (Europe), NovaTears[4] (Australia, New Zealand), and Miebo[5] (USA), is a medication used for the treatment of dry eye disease.[2] It is a semifluorinated alkane.[2]
Perfluorohexyloctane has been available in multiple markets since 2015 under the brand names EvoTears and NovaTears,[6] and was additionally approved for medical use in the United States in May 2023 under the brand Miebo.[2][7] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[8]
Perfluorohexyloctane when sold under the brand names EvoTears or NovaTears is available in multiple countries over-the-counter[9] costing NZ$34.00,[10] A$30,[11] and €30[12] for approximately a one-month supply. When sold in the USA under the brand Miebo a prescription is required.
Medical uses
[edit]Perfluorohexyloctane is indicated for the treatment of the signs and symptoms of dry eye disease.[2][13][14]
See also
[edit]
References
[edit]- ^ "Notice: Multiple additions to the Prescription Drug List (PDL) [2024-10-18]". Health Canada. 18 October 2024. Retrieved 25 October 2024.
- ^ a b c d e "Miebo- perfluorohexyloctane solution". DailyMed. 18 May 2023. Retrieved 8 June 2023.
- ^ "EvoTears - Official Website". Retrieved 15 February 2024.
- ^ "NovaTears - AFT Pharmaceuticals". Retrieved 15 February 2024.
- ^ "MIEBO (perfluorohexyloctane ophthalmic solution) | RX Dry Eye Drops". www.miebo.com. Retrieved 5 June 2024.
- ^ "URSAPHARM GmbH and Novaliq GmbH Announce European Partnership Agreement". Retrieved 15 February 2024.
- ^ "Bausch + Lomb and Novaliq Announce FDA Approval of Miebo (Perfluorohexyloctane Ophthalmic Solution) for the Treatment of the Signs and Symptoms of Dry Eye Disease" (Press release). Bausch + Lomb Corporation. 18 May 2023. Retrieved 8 June 2023 – via Business Wire.
- ^ New Drug Therapy Approvals 2023 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2024. Archived from the original on 10 January 2024. Retrieved 9 January 2024.
- ^ "Global Availability Announcement". Retrieved 15 February 2024.
- ^ "Novatears 3ml - Life Pharmacy New Zealand". Retrieved 15 February 2024.
- ^ "NovaTears Preservative Free Lubricating Eye Drops 3ml - Chemist Warehouse Australia". Retrieved 15 February 2024.
- ^ "Evotears Eye Drops 3ml - Amazon.de". Amazon Germany. Retrieved 15 February 2024.
- ^ Ballesteros-Sánchez A, De-Hita-Cantalejo C, Sánchez-González MC, Jansone-Langine Z, de Sotomayor MA, Culig J, et al. (October 2023). "Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent". The Ocular Surface. 30: 254–262. doi:10.1016/j.jtos.2023.10.001. hdl:11441/151762. PMID 37813152. S2CID 263802332.
- ^ Sheppard JD, Evans DG, Protzko EE (November 2023). "A review of the first anti-evaporative prescription treatment for dry eye disease: perfluorohexyloctane ophthalmic solution". The American Journal of Managed Care. 29 (14 Suppl): S251–S259. doi:10.37765/ajmc.2023.89464. PMID 37930231. S2CID 265032840.