Peptidase inhibitor 15

PI15
Identifiers
Aliases	PI15, CRISP8, P24TI, P25TI, peptidase inhibitor 15
External IDs	OMIM: 607076; MGI: 1934659; HomoloGene: 22935; GeneCards: PI15; OMA:PI15 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	74,855,029 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	17,701,163 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; lactiferous duct; ; appendix; ; left uterine tube; ; seminal vesicula; ; cartilage tissue; ; smooth muscle tissue; ; prostate; ; visceral pleura; ; urethra;
	Top expressed in
	ascending aorta; ; aortic valve; ; glomerulus; ; uterus; ; decidua; ; tunica media of zone of aorta; ; Bowman's capsule; ; vas deferens; ; esophagus; ; endothelial cell of lymphatic vessel;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity;
Cellular component	extracellular exosome; extracellular region; extracellular space;
Biological process	negative regulation of peptidase activity; multicellular organism development; biological process;
	Sources:Amigo / QuickGO
Orthologs
	51050
	94227
	ENSG00000137558
	ENSMUSG00000067780
	O43692
	Q8BS03
	NM_015886; NM_001324403
	NM_053191
	NP_001311332; NP_056970
	NP_444421
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene. ^[5]

Function

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067780 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Peptidase inhibitor 15". Retrieved 2018-08-01.

Function

References

Further reading