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Pegargiminase

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Pegargiminase
Clinical data
Other namesADI-PEG20
Identifiers
CAS Number
PubChem SID
DrugBank
UNII
ChEMBL

Pegargiminase (also known as pegylated arginine deiminase) is an investigational drug used in arginine deprivation therapy for treating cancers deficient in argininosuccinate synthetase 1 (ASS1).[1][2][3][4] It is a recombinant form of the enzyme arginine deiminase cloned from the bacteria Mycoplasma hominus and synthesized in Escherichia coli. It has been pegylated to improve the half-life and reduce immunogenicity.[1]

References

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  1. ^ a b Feun L, Savaraj N (July 2006). "Pegylated arginine deiminase: a novel anticancer enzyme agent". Expert Opinion on Investigational Drugs. 15 (7): 815–22. doi:10.1517/13543784.15.7.815. PMC 3086545. PMID 16787144.
  2. ^ Kuo MT, Savaraj N, Feun LG (August 2010). "Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes". Oncotarget. 1 (4): 246–51. doi:10.18632/oncotarget.135. PMC 2998341. PMID 21152246.
  3. ^ Synakiewicz A, Stachowicz-Stencel T, Adamkiewicz-Drozynska E (November 2014). "The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials". Expert Opinion on Investigational Drugs. 23 (11): 1517–29. doi:10.1517/13543784.2014.934808. PMID 24965808.
  4. ^ Field GC, Pavlyk I, Szlosarek PW (February 2023). "Bench-to-Bedside Studies of Arginine Deprivation in Cancer". Molecules. 28 (5). Basel, Switzerland: 2150. doi:10.3390/molecules28052150. PMC 10005060. PMID 36903394.