PSRC1

PSRC1
Identifiers
Aliases	PSRC1, DDA3, FP3214, proline and serine rich coiled-coil 1
External IDs	OMIM: 613126; MGI: 1913099; HomoloGene: 49603; GeneCards: PSRC1; OMA:PSRC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,283,186 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,295,547 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; ventricular zone; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; hippocampus proper; ; right frontal lobe; ; Brodmann area 9; ; substantia nigra; ; anterior cingulate cortex; ; primary visual cortex;
	Top expressed in
	zygote; ; secondary oocyte; ; ventricular zone; ; primary oocyte; ; genital tubercle; ; epiblast; ; condyle; ; calvaria; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; microtubule binding;
Cellular component	spindle microtubule; cytoskeleton; spindle; cytosol; microtubule cytoskeleton; spindle pole; midbody; cytoplasm; nucleoplasm;
Biological process	mitotic metaphase plate congression; negative regulation of cell growth; microtubule bundle formation; regulation of mitotic spindle organization; cell division; cell cycle; cellular process; positive regulation of transcription, DNA-templated; positive regulation of microtubule polymerization; positive regulation of cyclin-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	84722
	56742
	ENSG00000134222
	ENSMUSG00000068744
	Q6PGN9; Q5T2Z0
	Q9D0P7
NM_001005290; NM_001032290; NM_001032291; NM_032636; NM_001350237;
	NM_001350238; NM_001350239; NM_001350240; NM_001350241; NM_001350242; NM_001363309; NM_001394002; NM_001394003; NM_001394004; NM_001394005
	NM_001190161; NM_019976
NP_001005290; NP_001027462; NP_116025; NP_001337166; NP_001337167;
	NP_001337168; NP_001337169; NP_001337170; NP_001337171; NP_001350238
	NP_001177090; NP_064360
	Wikidata
View/Edit Human	View/Edit Mouse

Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene.^[5]^[6]^[7]

This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134222 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068744 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID 12427559.
^ Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi:10.1038/sj.onc.1203167. PMID 10618717.
^ ^a ^b "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".

Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC 2682493. PMID 18193044.
Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia". Am. J. Hum. Genet. 82 (1): 139–49. doi:10.1016/j.ajhg.2007.11.001. PMC 2253977. PMID 18179892.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134222 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068744 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12427559-5] Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2–3): 214–8. doi:10.1016/s0167-4781(02)00512-2. PMID 12427559.

[pmid10618717-6] Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". Oncogene. 18 (54): 7765–74. doi:10.1038/sj.onc.1203167. PMID 10618717.

[entrez-7] "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1".

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[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading