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PPM1G

From Wikipedia, the free encyclopedia
PPM1G
Identifiers
AliasesPPM1G, PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase, Mg2+/Mn2+ dependent 1G
External IDsOMIM: 605119; MGI: 106065; HomoloGene: 31106; GeneCards: PPM1G; OMA:PPM1G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_177983

NM_008014

RefSeq (protein)

NP_817092
NP_817092.1

NP_032040

Location (UCSC)Chr 2: 27.38 – 27.41 MbChr 5: 31.36 – 31.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene.[5][6]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115241Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029147Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Travis SM, Welsh MJ (Sep 1997). "PP2C gamma: a human protein phosphatase with a unique acidic domain". FEBS Lett. 412 (3): 415–9. doi:10.1016/S0014-5793(97)00837-5. PMID 9276438. S2CID 82436336.
  6. ^ a b "Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform".

Further reading

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