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Protein-coding gene in the species Homo sapiens
Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[ 7]
PPFIBP1 has been shown to interact with liprin-alpha-1 .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000110841 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016487 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins" . J Biol Chem . 273 (25): 15611–20. doi :10.1074/jbc.273.25.15611 PMID 9624153 . ^ Kriajevska M, Fischer-Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, Ambartsumian N, Lukanidin E (Feb 2002). "Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)" . J Biol Chem . 277 (7): 5229–35. doi :10.1074/jbc.M110976200 PMID 11836260 . ^ a b "Entrez Gene: PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)" .
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