PJA2

PJA2
Identifiers
Aliases	PJA2, Neurodap1, RNF131, praja ring finger ubiquitin ligase 2
External IDs	MGI: 2159342; HomoloGene: 32233; GeneCards: PJA2; OMA:PJA2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	109,409,974 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	64,638,911 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; postcentral gyrus; ; frontal pole; ; Achilles tendon; ; Brodmann area 46; ; prefrontal cortex; ; orbitofrontal cortex; ; pons; ; caput epididymis; ; superior vestibular nucleus;
	Top expressed in
	interventricular septum; ; medial dorsal nucleus; ; dorsal striatum; ; temporal lobe; ; olfactory tubercle; ; globus pallidus; ; inferior colliculi; ; facial motor nucleus; ; Region I of hippocampus proper; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase A regulatory subunit binding; ubiquitin-protein transferase activity; protein kinase A catalytic subunit binding; ubiquitin protein ligase activity; metal ion binding; transferase activity; protein binding;
Cellular component	Golgi membrane; postsynaptic density; membrane; endoplasmic reticulum; synapse; plasma membrane; cytoplasm; cell junction; postsynaptic membrane; Golgi apparatus; intermediate filament cytoskeleton; endoplasmic reticulum membrane;
Biological process	hippo signaling; regulation of protein kinase A signaling; long-term memory; protein ubiquitination; inflammatory response; positive regulation of toll-like receptor 2 signaling pathway; regulation of macrophage activation; innate immune response; positive regulation of JNK cascade; positive regulation of p38MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	9867
	224938
	ENSG00000198961
	ENSMUSG00000024083
	O43164
	Q80U04
	NM_014819
	NM_001025309; NM_144859
	NP_055634
	NP_001020480; NP_659108
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene.^[5]

Interactions

PJA2 has been shown to interact with UBE2D2.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198961 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024083 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".
^ Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Miyake T, Gahara Y, Ohara O, Kitamura T (July 1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse". The Journal of Neuroscience. 15 (7 Pt 2): 5238–48. doi:10.1523/JNEUROSCI.15-07-05238.1995. PMC 6577874. PMID 7623148.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198961 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024083 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".

[pmid12036302-6] Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.

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Interactions

References

Further reading