PDE6C

PDE6C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JWQ, 3JWR, 5E8F
Identifiers
Aliases	PDE6C, ACHM5, COD4, PDEA2, phosphodiesterase 6C
External IDs	OMIM: 600827; MGI: 105956; HomoloGene: 4521; GeneCards: PDE6C; OMA:PDE6C - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	93,666,010 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	38,172,406 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; ectocervix; ; tibial nerve; ; right lung; ; gastrocnemius muscle; ; canal of the cervix; ; body of uterus;
	Top expressed in
	neural layer of retina; ; pineal gland; ; epithelium of lens; ; yolk sac; ; retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; embryo; ; liver; ; primitive streak; ; iris;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoric diester hydrolase activity; nucleotide binding; cGMP binding; 3',5'-cyclic-GMP phosphodiesterase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding;
Cellular component	plasma membrane; membrane;
Biological process	sensory perception of light stimulus; retinal cone cell development; signal transduction; visual perception; phototransduction, visible light; response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5146
	110855
	ENSG00000095464
	ENSMUSG00000024992
	P51160
	Q91ZQ1
	NM_006204
	NM_001170959; NM_033614
	NP_006195
	NP_001164430; NP_291092
	Wikidata
View/Edit Human	View/Edit Mouse

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime".

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–381. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bertazolli-Filho R, Ghosh S, Huang W, et al. (2001). "Molecular evidence that human ocular ciliary epithelium expresses components involved in phototransduction". Biochem. Biophys. Res. Commun. 284 (2): 317–325. doi:10.1006/bbrc.2001.4970. PMID 11394879.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Gao YQ, Danciger M, Longmuir R, et al. (1999). "Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations". Invest. Ophthalmol. Vis. Sci. 40 (8): 1818–1822. PMID 10393054.
Feshchenko EA, Andreeva SG, Suslova VA, et al. (1996). "Human cone-specific cGMP phosphodiesterase alpha' subunit: complete cDNA sequence and gene arrangement". FEBS Lett. 381 (1–2): 149–152. doi:10.1016/0014-5793(96)00104-4. PMID 8641425. S2CID 86278856.
Viczian AS, Piriev NI, Farber DB (1996). "Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase". Gene. 166 (2): 205–211. doi:10.1016/0378-1119(95)00585-4. PMID 8543163.
Piriev NI, Viczian AS, Ye J, et al. (1996). "Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24". Genomics. 28 (3): 429–435. doi:10.1006/geno.1995.1171. PMID 7490077.

External links

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024992 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime".

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References

Further reading

External links