PAR1 (gene)

PWAR1
Identifiers
Aliases	PWAR1, D15S227E, PAR-1, PAR1, Prader Willi/Angelman region RNA 1
External IDs	OMIM: 600161; GeneCards: PWAR1; OMA:PWAR1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	25,138,055 bp
RNA expression pattern
	Top expressed in
	testicle; ; skeletal muscle tissue; ; muscle of leg; ; ganglionic eminence; ; primary visual cortex; ; muscle of thigh; ; right lobe of thyroid gland; ; prefrontal cortex; ; superior frontal gyrus; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	n/a
Orthologs
	145624
	n/a
	ENSG00000279050
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Prader-Willi/Angelman region-1, also known as PWAR1, is an exon of the lncRNA Small nucleolar RNA host gene 14 (SNHG14).^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000279050 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PAR1 Prader-Willi/Angelman region-1".

Sutcliffe JS, Nakao M, Christian S, et al. (1995). "Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region". Nat. Genet. 8 (1): 52–8. doi:10.1038/ng0994-52. PMID 7987392. S2CID 31504627.
Schulze A, Hansen C, Skakkebaek NE, et al. (1996). "Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint". Nat. Genet. 12 (4): 452–4. doi:10.1038/ng0496-452. PMID 8630505. S2CID 22259236.
Christian SL, Bhatt NK, Martin SA, et al. (1998). "Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb". Genome Res. 8 (2): 146–57. doi:10.1101/gr.8.2.146. PMC 310691. PMID 9477342.
Wirth J, Back E, Hüttenhofer A, et al. (2001). "A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15". Hum. Mol. Genet. 10 (3): 201–10. doi:10.1093/hmg/10.3.201. PMID 11159938.
Dorsam RT, Tuluc M, Kunapuli SP (2005). "Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets". J. Thromb. Haemost. 2 (5): 804–12. doi:10.1111/j.1538-7836.2004.00692.x. PMID 15099288. S2CID 20124469.
Nakayama T, Hirano K, Hirano M, et al. (2004). "Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells". Biochem. Pharmacol. 68 (1): 23–32. doi:10.1016/j.bcp.2004.03.005. PMID 15183114.
Shi X, Gangadharan B, Brass LF, et al. (2005). "Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis". Mol. Cancer Res. 2 (7): 395–402. doi:10.1158/1541-7786.395.2.7. PMID 15280447. S2CID 31329993.
Heider I, Schulze B, Oswald E, et al. (2005). "PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism". Oncol. Res. 14 (10): 475–82. doi:10.3727/0965040042380496. PMID 15559761.
Tantivejkul K, Loberg RD, Mawocha SC, et al. (2005). "PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism" (PDF). J. Cell. Biochem. 96 (3): 641–52. doi:10.1002/jcb.20533. hdl:2027.42/48764. PMID 16052512. S2CID 34707839.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000279050 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: PAR1 Prader-Willi/Angelman region-1".

[1]

[2]

[3]

References

Further reading