Organification

Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO)^[1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".^[2]

Thionamides can block organification.^[3]

References

^ Shargel L, Mutnick AH, Souney PF (May 2007). Comprehensive Pharmacy Review. Lippincott Williams and Wilkins. p. 1181. ISBN 978-0-7817-7403-1.
^ Molinam PE, Ashman R. Endocrine Physiology (Third ed.). McGraw Hill Professional. p. 81. ISBN 978-0-07-161302-6.
^ Aronson JK, ed. (January 2016). "Thionamides". Meyler's Side Effects of Drugs (Sixteenth Edition). Oxford: Elsevier. pp. 874–889. doi:10.1016/b978-0-444-53717-1.01537-7. ISBN 978-0-444-53716-4. Retrieved 2021-02-18.

[1] Shargel L, Mutnick AH, Souney PF (May 2007). Comprehensive Pharmacy Review. Lippincott Williams and Wilkins. p. 1181. ISBN 978-0-7817-7403-1.

[2] Molinam PE, Ashman R. Endocrine Physiology (Third ed.). McGraw Hill Professional. p. 81. ISBN 978-0-07-161302-6.

[3] Aronson JK, ed. (January 2016). "Thionamides". Meyler's Side Effects of Drugs (Sixteenth Edition). Oxford: Elsevier. pp. 874–889. doi:10.1016/b978-0-444-53717-1.01537-7. ISBN 978-0-444-53716-4. Retrieved 2021-02-18.

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