Organification

Organification is a biochemical process that takes place in the thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).^[1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".^[2]

Thionamides can block organification.^[3]

References

^ Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p1181.
^ Endocrine Physiology, Patricia E. Molina, third edition, p81.
^ Aronson, J. K., ed. (2016-01-01), "Thionamides", Meyler's Side Effects of Drugs (Sixteenth Edition), Oxford: Elsevier, pp. 874–889, doi:10.1016/b978-0-444-53717-1.01537-7, ISBN 978-0-444-53716-4, retrieved 2021-02-18

[1] Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p1181.

[2] Endocrine Physiology, Patricia E. Molina, third edition, p81.

[3] Aronson, J. K., ed. (2016-01-01), "Thionamides", Meyler's Side Effects of Drugs (Sixteenth Edition), Oxford: Elsevier, pp. 874–889, doi:10.1016/b978-0-444-53717-1.01537-7, ISBN 978-0-444-53716-4, retrieved 2021-02-18

[1]

[2]

[3]