The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.[6]
Stoffler D, Fahrenkrog B, Aebi U (1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Curr. Opin. Cell Biol. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID10395558.
Hood JK, Silver PA (2000). "Diverse nuclear transport pathways regulate cell proliferation and oncogenesis". Biochim. Biophys. Acta. 1471 (1): M31–41. doi:10.1016/s0304-419x(00)00018-4. PMID10967423.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G (1997). "Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32". Genomics. 42 (3): 538–40. doi:10.1006/geno.1997.4767. PMID9205132.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Martínez N, Alonso A, Moragues MD, Pontón J, Schneider J (1999). "The nuclear pore complex protein Nup88 is overexpressed in tumor cells". Cancer Res. 59 (21): 5408–11. PMID10554006.
Gould VE, Orucevic A, Zentgraf H, Gattuso P, Martinez N, Alonso A (2002). "Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis". Hum. Pathol. 33 (5): 536–44. doi:10.1053/hupa.2002.124785. PMID12094380.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243. S2CID14294292.