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Niveen Khashab

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Niveen M. Khashab is a Lebanese chemist and an associate Professor of chemical Sciences and engineering at King Abdullah University of Science and Technology in Saudi Arabia since 2009.[1][2] She is a laureate of the 2017 L'Oréal-UNESCO Awards for Women in Science "for her contributions to innovative smart hybrid materials aimed at drug delivery and for developing new techniques to monitor intracellular antioxidant activity."[3] She is also a fellow of the Royal Chemical Society, and a member of the American Chemical Society.[4]

Education

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Niveen M. Khashab received her B.S. in Chemistry from the American University of Beirut, Lebanon, followed by her PhD in chemistry at the University of Florida.[5][6]

Research & Career

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Professor Khashab's research focuses on the design, synthesis, and use of "smart" programmable nanomaterials, emphasizing the systems' controlled release and delivery characteristics.[7][8][9] These synthetic materials are applied for biomimetic biological (distribution, sensing, and imaging), industrial (nanocomposites), and environmental (synthesis of membranes) applications, respectively.[10][11][12][13] Niveen's research interests include leveraging the natural microporosity of supramolecular assemblies for energy-intensive separations. Her research team is particularly interested in the separation of benzene derivatives employing macrocycles and cages designed for optimal separation via molecular recognition.[14] Her team has produced a variety of self-assembled capsules (SACs) for the encapsulation and transport of RNA, DNA, and proteins. She focuses on the encapsulation and delivery of CRISPR-Cas9 to enhance targeted gene editing.[15][16]

With more than ten years of professional experience, Prof. Niveen M. Khashab is presently a Full Professor and Head of the Chemistry Program at the King Abdullah University of Science and Technology.

Bibliography

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  • Carbon Nanomaterials Sourcebook: Graphene, Fullerenes, Nanotubes, and Nanodiamonds, Volume I.[17]

Patents

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Prof. Niveen M. Khashab has obtained many patents for her inventions including:

  • Compositions of graphene materials with metal nanostructures and microstructures and methods of making and using including pressure sensors (US10807048B2)[18]
  • Magnetically controlled permeability membranes (US20180296469A1)[19]
  • Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same (EP3471864A1)[20]
  • Nanocluster capped mesoporous nanoparticles, methods of making and use (US20200046849A1)[21]
  • Polymer carbon nanotube composite (US20160297952A1)[22]
  • Polymer nanocomposites and methods of making nanocomposites (US9650494B2)[23]
  • Separating aromatic isomers using aqueous solutions of cucurbituril macrocycles (WO2021124219A1)[24]
  • Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same (US20200306701A1)[25]
  • Encoding Raman spectral data in optical identification tags for analyte identification (WO2021053409A1)[26]

Publications

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  • Jonas G. Croissant, Yevhen Fatieiev, Niveen M. Khashab. "Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles". WIley Online Library.[27]
  • Jonas G. Croissant, Yevhen Fatieiev, Abdulaziz Almalik, Niveen M. Khashab. "Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications". WIley Online Library.[28]
  • Shahad K Alsaiari, Sachin Patil, Mram Alyami, Kholod O Alamoudi, Fajr A Aleisa, Jasmeen S Merzaban, Mo Li, and Niveen M Khashab. "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". ACS Publications.[29]
  • Jonas G. Croissant, Xavier Cattoën, Michel Wong Chi Man, Jean-Olivier Durand and Niveen M. Khashab. "Syntheses and applications of periodic mesoporous organosilica nanoparticles". Nanoscale.[30]
  • Jonas G Croissant, Dingyuan Zhang, Shahad Alsaiari, Jie Lu, Lin Deng, Fuyuhiko Tamanoi, Abdulaziz M AlMalik, Jeffrey I Zink, and Niveen M Khashab. "Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging". Journal of Controlled Release.[31]
  • Mram Z Alyami, Shahad K Alsaiari, Yanyan Li, Somayah S Qutub, Fajr A Aleisa, Rachid Sougrat, Jasmeen S Merzaban, and Niveen M Khashab. "Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks". ACS Publications.[32]

Awards

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Niveen won the Great Arab Minds Award in Natural Sciences in 2023 for her contributions to chemistry, bioengineering, and biology.[33]

References

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  1. ^ Niveen Khashab's page on King Abdullah University of Science and Technology's website
  2. ^ "Her CV" (PDF). Archived from the original (PDF) on 2016-10-14. Retrieved 2016-10-13.
  3. ^ Announcement of Laureates of 2017 L’Oréal-UNESCO For Women in Science Awards Archived 2016-10-10 at the Wayback Machine
  4. ^ "Congratulations to the 2023 Cram Lehn Pedersen Prize Winner: Niveen Khashab – Chemical Communications Blog". Retrieved 2023-03-03.
  5. ^ "Niveen Khashab". KAUST PORTAL FOR RESEARCHERS AND STUDENTS. Retrieved 2023-03-03.
  6. ^ "A young researcher in the spotlight: Niveen M. Khashab - ISGS". 2019-03-29. Retrieved 2023-03-03.
  7. ^ International, Drug Patents (2016-01-03). "One Organic Chemist One Day: Niveen M. Khashab". One Organic Chemist One Day. Retrieved 2023-03-03.
  8. ^ Min Song, Hyon; H. Anjum, Dalaver; M. Khashab, Niveen (2012). "Shape-controlled synthesis of Au@Pd core-shell nanoparticles and their corresponding electrochemical properties". RSC Advances. 2 (9): 3621–3624. Bibcode:2012RSCAd...2.3621S. doi:10.1039/C2RA20152F.
  9. ^ Li, Song; Li, Wengang; Khashab, Niveen M. (2012-12-01). "Stimuli responsive nanomaterials for controlled release applications". Nanotechnology Reviews. 1 (6): 493–513. doi:10.1515/ntrev-2012-0033. ISSN 2191-9097. S2CID 135482439.
  10. ^ Huang, Guoyou; Li, Fei; Zhao, Xin; Ma, Yufei; Li, Yuhui; Lin, Min; Jin, Guorui; Lu, Tian Jian; Genin, Guy M.; Xu, Feng (2017-10-25). "Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment". Chemical Reviews. 117 (20): 12764–12850. doi:10.1021/acs.chemrev.7b00094. ISSN 0009-2665. PMC 6494624. PMID 28991456.
  11. ^ Chand, Santanu; Alahmed, Othman; Baslyman, Walaa S.; Dey, Avishek; Qutub, Somayah; Saha, Ranajit; Hijikata, Yuh; Alaamery, Manal; Khashab, Niveen M. (2022-03-28). "DNA-Mimicking Metal–Organic Frameworks with Accessible Adenine Faces for Complementary Base Pairing". JACS Au. 2 (3): 623–630. doi:10.1021/jacsau.1c00516. ISSN 2691-3704. PMC 8969998. PMID 35373199.
  12. ^ Alimi, Lukman O.; Fang, Fang; Moosa, Basem; Ding, Yanjun; Khashab, Niveen M. (2022-10-24). "Vapor-Triggered Mechanical Actuation in Polymer Composite Films Based on Crystalline Organic Cages". Angewandte Chemie International Edition. 61 (43): e202212596. doi:10.1002/anie.202212596. hdl:10754/680836. ISSN 1433-7851. PMID 36047488. S2CID 251978883.
  13. ^ Huang, Tiefan; Moosa, Basem A.; Hoang, Phuong; Liu, Jiangtao; Chisca, Stefan; Zhang, Gengwu; AlYami, Mram; Khashab, Niveen M.; Nunes, Suzana P. (2020-11-18). "Molecularly-porous ultrathin membranes for highly selective organic solvent nanofiltration". Nature Communications. 11 (1): 5882. Bibcode:2020NatCo..11.5882H. doi:10.1038/s41467-020-19404-6. ISSN 2041-1723. PMC 7674481. PMID 33208753.
  14. ^ Zhang, Gengwu; Hua, Bin; Dey, Avishek; Ghosh, Munmun; Moosa, Basem A.; Khashab, Niveen M. (2021-01-05). "Intrinsically Porous Molecular Materials (IPMs) for Natural Gas and Benzene Derivatives Separations". Accounts of Chemical Research. 54 (1): 155–168. doi:10.1021/acs.accounts.0c00582. ISSN 0001-4842. PMID 33332097. S2CID 229316181.
  15. ^ O. Alimi, Lukman; Z. Alyami, Mram; Chand, Santanu; Baslyman, Walaa; M. Khashab, Niveen (2021). "Coordination-based self-assembled capsules (SACs) for protein, CRISPR–Cas9, DNA and RNA delivery". Chemical Science. 12 (7): 2329–2344. doi:10.1039/D0SC05975G. PMC 8179292. PMID 34163998.
  16. ^ Alsaiari, Shahad K; Patil, Sachin; Alyami, Mram; Alamoudi, Kholod O; Aleisa, Fajr A; Merzaban, Jasmeen S; Li, Mo; Khashab, Niveen M (2018-01-01). "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". Journal of the American Chemical Society. 140 (1): 143–146. Bibcode:2018JAChS.140..143A. doi:10.1021/jacs.7b11754. hdl:10754/626437. ISSN 1520-5126. PMID 29272114.
  17. ^ Carbon nanomaterials sourcebook. Volume 1, Graphene, fullerenes, nanotubes, and nanodiamonds. Klaus D. Sattler. Boca Raton, FL. 2016. ISBN 978-1-4822-5269-9. OCLC 945552732.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  18. ^ US10807048B2, KHASHAB, Niveen M.; Chen, Ye & Tao, Jing, "Compositions of graphene materials with metal nanostructures and microstructures and methods of making and using including pressure sensors", issued 2020-10-20 
  19. ^ US20180296469A1, Kosel, Jürgen; Khashab, Niveen & Zaher, Amir, "Magnetically controlled permeability membranes", issued 2018-10-18 
  20. ^ EP3471864A1, HAMMAMI, Mohamed Amen; Francis, Lijo & CROISSANT, Jonas et al., "Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same", issued 2019-04-24 
  21. ^ US20200046849A1, ALSAIARI, Shahad; HAMMAMI, Mohamed Amen & KHASHAB, Niveen M., "Nanocluster capped mesoporous nanoparticles, methods of making and use", issued 2020-02-13 
  22. ^ US20160297952A1, Chen, Ye; Tao, Jing & Deng, Lin et al., "Polymer carbon nanotube composite", issued 2016-10-13 
  23. ^ US9650494B2, Chen, Ye; Tao, Jing & Deng, Lin et al., "Polymer nanocomposites and methods of making nanocomposites", issued 2017-05-16 
  24. ^ WO2021124219A1, ZHANG, Gengwu & KHASHAB, Niveen M., "Separating aromatic isomers using aqueous solutions of cucurbituril macrocycles", issued 2021-06-24 
  25. ^ US20200306701A1, HAMMAMI, Mohamed Amen; FRANCIS, Lijo & CROISSANT, Jonas et al., "Periodic mesoporous organosilica-doped nanocomposite membranes and systems including same", issued 2020-10-01 
  26. ^ WO2021053409A1, KHASHAB, Niveen M. & HOANG, Phuong Mai, "Encoding raman spectral data in optical identification tags for analyte identification", issued 2021-03-25 
  27. ^ Croissant, Jonas G.; Fatieiev, Yevhen; Khashab, Niveen M. (March 2017). "Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles". Advanced Materials. 29 (9): 1604634. Bibcode:2017AdM....2904634C. doi:10.1002/adma.201604634. PMID 28084658. S2CID 205274162.
  28. ^ Croissant, Jonas G.; Fatieiev, Yevhen; Almalik, Abdulaziz; Khashab, Niveen M. (February 2018). "Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications". Advanced Healthcare Materials. 7 (4): 1700831. doi:10.1002/adhm.201700831. hdl:10754/626577. PMID 29193848. S2CID 3445633.
  29. ^ Alsaiari, Shahad K.; Patil, Sachin; Alyami, Mram; Alamoudi, Kholod O.; Aleisa, Fajr A.; Merzaban, Jasmeen S.; Li, Mo; Khashab, Niveen M. (2018-01-10). "Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework". Journal of the American Chemical Society. 140 (1): 143–146. Bibcode:2018JAChS.140..143A. doi:10.1021/jacs.7b11754. hdl:10754/626437. ISSN 0002-7863. PMID 29272114.
  30. ^ Croissant, Jonas G.; Cattoën, Xavier; Man, Michel Wong Chi; Durand, Jean-Olivier; Khashab, Niveen M. (2015-12-03). "Syntheses and applications of periodic mesoporous organosilica nanoparticles". Nanoscale. 7 (48): 20318–20334. Bibcode:2015Nanos...720318C. doi:10.1039/C5NR05649G. ISSN 2040-3372. PMID 26585498.
  31. ^ Croissant, Jonas G.; Zhang, Dingyuan; Alsaiari, Shahad; Lu, Jie; Deng, Lin; Tamanoi, Fuyuhiko; AlMalik, Abdulaziz M.; Zink, Jeffrey I.; Khashab, Niveen M. (2016-05-10). "Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging". Journal of Controlled Release. 229: 183–191. doi:10.1016/j.jconrel.2016.03.030. hdl:10754/603622. ISSN 0168-3659. PMID 27016140.
  32. ^ Alyami, Mram Z.; Alsaiari, Shahad K.; Li, Yanyan; Qutub, Somayah S.; Aleisa, Fajr A.; Sougrat, Rachid; Merzaban, Jasmeen S.; Khashab, Niveen M. (2020-01-29). "Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks". Journal of the American Chemical Society. 142 (4): 1715–1720. Bibcode:2020JAChS.142.1715A. doi:10.1021/jacs.9b11638. hdl:10754/678579. ISSN 0002-7863. PMID 31931564. S2CID 210194377.
  33. ^ "Lebanese Prof. Niveen Khashab Wins Great Arab Minds Award in Natural Sciences". english.aawsat.com. Retrieved 2024-07-31.
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