NVL (gene)

NVL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X8A
Identifiers
Aliases	NVL, NVL2, nuclear VCP-like, nuclear VCP like
External IDs	OMIM: 602426; MGI: 1914709; HomoloGene: 1902; GeneCards: NVL; OMA:NVL - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.11 Start 224,227,334 bp End 224,330,189 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H4 Start 180,914,703 bp End 180,971,769 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon mucosa of transverse colon ventricular zone ganglionic eminence gonad cerebellar hemisphere right hemisphere of cerebellum testicle skin of abdomen Top expressed in tail of embryo genital tubercle cumulus cell ventricular zone superior frontal gyrus epiblast spermatocyte morula ankle joint Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding preribosome binding protein binding ATP binding RNA binding ATPase activity Cellular component nucleolus membrane nucleus telomerase holoenzyme complex nucleoplasm nuclear exosome (RNase complex) Biological process ribosome biogenesis positive regulation of telomerase activity rRNA processing positive regulation of protein binding ribosomal large subunit biogenesis regulation of protein localization to nucleolus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4931 67459 Ensembl ENSG00000143748 ENSMUSG00000026516 UniProt O15381 Q9DBY8 RefSeq (mRNA) NM_001243146 NM_001243147 NM_002533 NM_206840 NM_026171 RefSeq (protein) NP_001230075 NP_001230076 NP_002524 NP_996671 NP_080447 Location (UCSC) Chr 1: 224.23 – 224.33 Mb Chr 1: 180.91 – 180.97 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nuclear valosin-containing protein-like is a protein that in humans is encoded by the NVL gene.

Further reading

• Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nagahama M, Hara Y, Seki A, et al. (2005). "NVL2 Is a Nucleolar AAA-ATPase that Interacts with Ribosomal Protein L5 through Its Nucleolar Localization Sequence". Mol. Biol. Cell. 15 (12): 5712–23. doi:10.1091/mbc.E04-08-0692. PMC 532049. PMID 15469983.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.