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Protein-coding gene in the species Homo sapiens
Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene .[ 5] [ 6] [ 7]
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere . Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation .
The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000143228 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026683 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wigge PA, Kilmartin JV (Mar 2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation" . J Cell Biol . 152 (2): 349–60. doi :10.1083/jcb.152.2.349 . PMC 2199619 PMID 11266451 . ^ Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma . 110 (5): 322–34. doi :10.1007/s004120100153 . PMID 11685532 . S2CID 22443613 . ^ a b "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)" .
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