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Protein-coding gene in the species Homo sapiens
Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene .[ 5]
Clinical significance [ edit ]
Variants of the NEGR1 gene may be associated with obesity and major depression.[ 6] [ 7] [ 8]
^ Jump up to: a b c GRCh38: Ensembl release 89: ENSG00000172260 – Ensembl , May 2017
^ Jump up to: a b c GRCm38: Ensembl release 89: ENSMUSG00000040037 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet . 41 (1): 18–24. doi :10.1038/ng.274 . PMID 19079260 . S2CID 764409 .
^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation" . Nat. Genet . 41 (1): 24–34. doi :10.1038/ng.287 . PMC 2695662 . PMID 19079261 .
^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI" . Obesity (Silver Spring) . 17 (12): 2254–7. doi :10.1038/oby.2009.159 . PMC 2860782 . PMID 19478790 .
Elortza F, Mohammed S, Bunkenborg J, et al. (2006). "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment". J. Proteome Res . 5 (4): 935–43. doi :10.1021/pr050419u . PMID 16602701 .
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Hom G, Graham RR, Modrek B, et al. (2008). "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX" . N. Engl. J. Med . 358 (9): 900–9. doi :10.1056/NEJMoa0707865 . PMID 18204098 .
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Yang Q, Kathiresan S, Lin JP, et al. (2007). "Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study" . BMC Med. Genet . 8 (Suppl 1): S12. doi :10.1186/1471-2350-8-S1-S12 . PMC 1995619 . PMID 17903294 .
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Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population" . J. Hum. Genet . 54 (12): 727–31. doi :10.1038/jhg.2009.106 . PMID 19851340 .
Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet . 41 (1): 18–24. doi :10.1038/ng.274 . PMID 19079260 . S2CID 764409 .