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NECAB3

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NECAB3
Identifiers
AliasesNECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDsOMIM: 612478; MGI: 1861721; HomoloGene: 10992; GeneCards: NECAB3; OMA:NECAB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031231
NM_031232

NM_021546
NM_001379147
NM_001379148
NM_001379149

RefSeq (protein)

NP_112508
NP_112509

NP_067521
NP_001366076
NP_001366077
NP_001366078

Location (UCSC)Chr 20: 33.66 – 33.67 MbChr 2: 154.39 – 154.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[5][6]

The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125967Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027489Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem. 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507.
  6. ^ a b "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".
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Further reading

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