NDST2

NDST2
Identifiers
Aliases	NDST2, HSST2, NST2, N-deacetylase/N-sulfotransferase 2, N-deacetylase and N-sulfotransferase 2, N-HSST 2
External IDs	OMIM: 603268; MGI: 97040; HomoloGene: 20803; GeneCards: NDST2; OMA:NDST2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,811,798 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,784,630 bp
RNA expression pattern
	Top expressed in
	spleen; ; granulocyte; ; blood; ; bone marrow; ; tonsil; ; right hemisphere of cerebellum; ; gastric mucosa; ; minor salivary glands; ; sural nerve; ; appendix;
	Top expressed in
	neural layer of retina; ; granulocyte; ; dermis; ; lip; ; ankle joint; ; ventricular zone; ; yolk sac; ; tail of embryo; ; spermatocyte; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; catalytic activity; hydrolase activity; N-acetylglucosamine deacetylase activity; [heparan sulfate-glucosamine N-sulfotransferase activity]; deacetylase activity; heparan sulfate sulfotransferase activity; heparan sulfate N-acetylglucosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	metabolism; heparan sulfate proteoglycan biosynthetic process; heparin biosynthetic process; glycosaminoglycan biosynthetic process; regulation of angiotensin levels in blood; cellular process or phenomenon; sulfur compound metabolic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	8509
	17423
	ENSG00000166507
	ENSMUSG00000039308
	P52849
	P52850
	NM_001330107; NM_003635
	NM_010811
	NP_001317036; NP_003626
	NP_034941
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166507 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039308 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. doi:10.1042/bj3320303. PMC 1219482. PMID 9601056.
^ "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme". Nature. 400 (6746): 773–6. Bibcode:1999Natur.400..773F. doi:10.1038/23488. PMID 10466727. S2CID 4428529.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039308 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9601056-5] Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. doi:10.1042/bj3320303. PMC 1219482. PMID 9601056.

[entrez-6] "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

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References

Further reading