NAP1L4

NAP1L4
Identifiers
Aliases	NAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDs	OMIM: 601651; MGI: 1316687; HomoloGene: 133933; GeneCards: NAP1L4; OMA:NAP1L4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,992,377 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,549,106 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; C1 segment; ; Achilles tendon; ; left testis; ; right testis; ; bone marrow cells; ; sural nerve; ; apex of heart; ; epithelium of colon;
	Top expressed in
	saccule; ; ectoderm; ; otic placode; ; otic vesicle; ; lens; ; epithelium of lens; ; medullary collecting duct; ; superior cervical ganglion; ; ventricular zone; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding; RNA binding; nucleosome binding;
Cellular component	nucleus; cytoplasm;
Biological process	nucleosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	4676
	17955
	ENSG00000205531; ENSG00000273562
	ENSMUSG00000059119
	Q99733
	Q78ZA7
	NM_005969
	NM_001285489; NM_001285490; NM_008672
NP_005960; NP_001356304; NP_001356305; NP_001356306; NP_001356307;
	NP_001356308; NP_001356309; NP_001356310; NP_001356311; NP_001356312; NP_001356313; NP_001356314; NP_001356315; NP_001356317; NP_005960.1
	NP_001272418; NP_001272419; NP_032698
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.^[5]^[6]

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.^[6]

References

^ ^a ^b ^c ENSG00000273562 GRCh38: Ensembl release 89: ENSG00000205531, ENSG00000273562 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi:10.1093/hmg/5.11.1743. PMID 8923002.
^ ^a ^b "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4".

Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". Genomics. 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID 9325046.
Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID 10764593.
Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Mol. Cell. Biol. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi:10.1073/pnas.142287999. PMC 123149. PMID 12089333.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID 15368365. S2CID 12368640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000273562 GRCh38: Ensembl release 89: ENSG00000205531, ENSG00000273562 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059119 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8923002-5] Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi:10.1093/hmg/5.11.1743. PMID 8923002.

[entrez-6] "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4".

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References

Further reading