Motile sperm domain containing 3

MOSPD3
Identifiers
Aliases	MOSPD3, CDS3, NET30, Motile sperm domain containing 3
External IDs	OMIM: 609125; MGI: 1916179; HomoloGene: 11406; GeneCards: MOSPD3; OMA:MOSPD3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,615,384 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,599,320 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right adrenal cortex; ; left adrenal cortex; ; skin of leg; ; ganglionic eminence; ; sperm; ; right lobe of liver; ; skin of abdomen; ; ectocervix;
	Top expressed in
	zygote; ; granulocyte; ; yolk sac; ; tail of embryo; ; right kidney; ; lip; ; genital tubercle; ; esophagus; ; neural tube; ; superior cervical ganglion;
	More reference expression data
	n/a
Orthologs
	64598
	68929
	ENSG00000106330
	ENSMUSG00000037221
	O75425
	Q8BGG6
NM_001040097; NM_001040098; NM_001040099; NM_023948; NM_001363415;
	NM_001363416
	NM_001254762; NM_030037
NP_001035186; NP_001035187; NP_001035188; NP_076438; NP_001350344;
	NP_001350345
	NP_001241691; NP_084313
	Wikidata
View/Edit Human	View/Edit Mouse

Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene.^[5]

Function

This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106330 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037221 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Motile sperm domain containing 3".

Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (October 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Research. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM (December 2004). "A novel transmembrane MSP-containing protein that plays a role in right ventricle development". Genomics. 84 (6): 1051–9. doi:10.1016/j.ygeno.2004.08.017. PMID 15533722.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AW, Akkermans JJ, Wijdeven RH, Janssen GM, van Veelen PA, Neefjes J (December 2020). "Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs". Cell Reports. 33 (10): 108475. doi:10.1016/j.celrep.2020.108475. hdl:1887/3184381. PMID 33296653. S2CID 228090430.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106330 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037221 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Motile sperm domain containing 3".

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Function

References

Further reading