Monocyte to macrophage differentiation factor

MMD
Identifiers
Aliases	MMD, MMA, MMD1, PAQR11, monocyte to macrophage differentiation associated
External IDs	OMIM: 604467; MGI: 1914718; HomoloGene: 8204; GeneCards: MMD; OMA:MMD - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	55,421,924 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	90,169,415 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; endothelial cell; ; orbitofrontal cortex; ; monocyte; ; Region I of hippocampus proper; ; amygdala; ; putamen; ; Brodmann area 46; ; buccal mucosa cell; ; entorhinal cortex;
	Top expressed in
	subiculum; ; white adipose tissue; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; olfactory tubercle; ; subcutaneous adipose tissue; ; amygdala; ; mammary gland; ; piriform cortex; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; signaling receptor activity;
Cellular component	lysosomal membrane; Golgi apparatus; integral component of plasma membrane; late endosome membrane; integral component of membrane; endosome; lysosome; membrane;
Biological process	cytolysis; regulation of protein localization; positive regulation of neuron differentiation; positive regulation of protein kinase activity; protein phosphorylation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23531
	67468
	ENSG00000108960
	ENSMUSG00000003948
	Q15546
	Q9CQY7
	NM_012329
	NM_026178; NM_001395423
	NP_036461
	NP_080454; NP_001382352
	Wikidata
View/Edit Human	View/Edit Mouse

Monocyte to macrophage differentiation factor also known as PAQR11 is a protein that in humans is encoded by the MMD gene. It is a member of the progestin and adipoQ receptor family.^[5] PAQR11 is a scaffold protein that is localized to the Golgi apparatus.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108960 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003948 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.
^ Peng W, Lei Q, Jiang Z, Hu Z (August 2014). "Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling". Journal of Molecular Histology. 45 (4): 435–45. doi:10.1007/s10735-013-9560-1. PMID 24337566.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108960 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003948 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16044242-5] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.

[Peng_2014-6] Peng W, Lei Q, Jiang Z, Hu Z (August 2014). "Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling". Journal of Molecular Histology. 45 (4): 435–45. doi:10.1007/s10735-013-9560-1. PMID 24337566.

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