Mogroside
A mogroside is a triterpene glycoside of cucurbitane derivatives found in certain plants, such as the fruit of the gourd vine Siraitia grosvenorii (known as monkfruit or luohan guo).[1][2] Mogrosides are extracted from S. grosvenorii and used in the manufacture of sugar substitutes.[1][2]
Mogrosides
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Mogrosides include:[1][2][failed verification][citation needed]
- Mogrol
- Mogroside II A1
- Mogroside II B
- 7-Oxomogroside II E
- 11-Oxomogroside A1
- Mogroside III A2
- 11-Deoxymogroside III
- 11-Oxomogroside IV A
- Mogroside V
- 7-Oxomogroside V
- 11-Oxo-mogroside V
- Mogroside VI
- Siamenoside I
The total content of mogrosides in Siraitia grosvenorii fruit is 3.8% with Mogroside V having the highest content (0.8% to 1.3% w/w).[3]
Biosynthesis
[edit]One analysis of 200 candidate genes of Siraitia grosvenorii revealed five enzyme families involved in the synthesis of mogroside V: squalene epoxidases, triterpenoid synthases, epoxide hydrolases, cytochrome P450s, and UDP-glucosyltransferases.[1] The metabolic pathway for mogroside biosynthesis involves an initial stage of fruit development when squalene is metabolized to di-glucosylated, tetra-hydroxycucurbitadienols, then during fruit maturation, branched glucosyl groups are added and catalyzed, leading to the sweet M4, M5, and M6 mogrosides.[1]
Stability
[edit]Mogroside V appears to be heat stable in the range of 100 to 150 degrees Celsius for 4 hours and up to 8 hours in boiling water. It is stable at a pH of between 3 and 12 when stored from 2 to 8 degrees Celsius.[4]
Uses
[edit]Some mogrosides are used in traditional Chinese medicine[2] and some are extracted for manufacturing as sweeteners.[1] Mogroside V extract from S. grosvenorii fruit is 250 times sweeter than sucrose,[1] sold commercially in Norbu (sweetener).
References
[edit]- ^ a b c d e f g Itkin, M.; Davidovich-Rikanati, R.; Cohen, S.; Portnoy, V.; Doron-Faigenboim, A.; Oren, E.; Freilich, S.; Tzuri, G.; Baranes, N.; Shen, S.; Petreikov, M.; Sertchook, R.; Ben-Dor, S.; Gottlieb, H.; Hernandez, A.; Nelson, D. R.; Paris, H. S.; Tadmor, Y.; Burger, Y.; Lewinsohn, E.; Katzir, N.; Schaffer, A. (2016). "The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii". Proceedings of the National Academy of Sciences of the United States of America. 113 (47): E7619 – E7628. Bibcode:2016PNAS..113E7619I. doi:10.1073/pnas.1604828113. PMC 5127336. PMID 27821754.
- ^ a b c d Subhuti Dharmananda (January 2004), "Luo han guo - Sweet fruit used as sugar substitute and medicinal herb". Institute for Traditional Medicine, Portland, Oregon.
- ^ Huang H, Peng Z, Wang W (2024). "A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications". Frontiers in Pharmacology. 15: 1388747. doi:10.3389/fphar.2024.1388747. PMC 11024725. PMID 38638866.
- ^ Younes, Maged; Aquilina, Gabriele; Engel, Karl-Heinz; Fowler, Paul; Frutos Fernandez, Maria Jose; Fürst, Peter; Gürtler, Rainer; Gundert-Remy, Ursula; Husøy, Trine; Mennes, Wim; Moldeus, Peter; Oskarsson, Agneta; Shah, Romina; Waalkens-Berendsen, Ine; Wölfle, Detlef; Degen, Gisela; Herman, Lieve; Gott, David; Leblanc, Jean-Charles; Giarola, Alessandra; Rincon, Ana Maria; Tard, Alexandra; Castle, Laurence (11 December 2019). "Safety of use of Monk fruit extract as a food additive in different food categories". EFSA Journal. 17 (12): e05921. doi:10.2903/j.efsa.2019.5921. PMC 7008860. PMID 32626208.
External links
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Media related to Mogrosides at Wikimedia Commons
