Mitochondrial translational release factor 1

MTRF1
Identifiers
Aliases	MTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1
External IDs	OMIM: 604601; MGI: 2384815; HomoloGene: 20903; GeneCards: MTRF1; OMA:MTRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	41,263,577 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	79,661,027 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; rectum; ; right adrenal gland; ; right adrenal cortex; ; gallbladder; ; left adrenal gland; ; granulocyte; ; testicle; ; left adrenal cortex; ; body of stomach;
	Top expressed in
	left ventricle; ; interventricular septum; ; quadriceps femoris muscle; ; primary oocyte; ; muscle tissue; ; proximal tubule; ; muscle of thigh; ; skeletal muscle tissue; ; right kidney; ; ovary;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation release factor activity; translation release factor activity, codon specific; ribosome binding;
Cellular component	mitochondrion; cytoplasm;
Biological process	translational termination; regulation of translational termination; protein biosynthesis; mitochondrial translational termination;
	Sources:Amigo / QuickGO
Orthologs
	9617
	211253
	ENSG00000120662
	ENSMUSG00000022022
	O75570; Q8N6Z2
	Q8K126
	NM_004294; NM_001354073; NM_001354074; NM_001354076
	NM_145960
	NP_004285; NP_001341002; NP_001341003; NP_001341005
	NP_666072
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.^[5]^[6]

The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
^ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.

Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816. S2CID 21204094.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939.
Young DJ, Edgar CD, Murphy J, et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria". RNA. 16 (6): 1146–55. doi:10.1261/rna.1970310. PMC 2874167. PMID 20421313.
Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism". Biology Direct. 7 (1): 14. doi:10.1186/1745-6150-7-14. PMC 3418547. PMID 22569235.
Lind, C; Sund J; Åqvist J (2013). "Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons". Nature Communications. 4: 2940. Bibcode:2013NatCo...4.2940L. doi:10.1038/ncomms3940. PMID 24352605.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9838146-5] Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.

[pmid10773675-6] Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.

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References

Further reading