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Martin Gruebele

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Martin Gruebele
Born (1964-01-10) January 10, 1964 (age 60)
Stuttgart, Germany
CitizenshipAmerican
Alma materUniversity of California, Berkeley, California Institute of Technology
Known forProtein folding, scanning tunneling microscopy, ultrafast laser spectroscopy
AwardsHans Neurath Award of the Protein Society, Nakanishi Prize, Sackler Prize, Friedrich Bessel Research Prize, Camille and Henry Dreyfus Foundation Fellowship
Scientific career
FieldsChemistry, Physics, Biophysics, Computational biology
InstitutionsUniversity of Illinois Urbana-Champaign
Academic advisorsRichard Saykally, Ahmed Zewail
Websitehttp://www.scs.illinois.edu/mgweb/

Martin Gruebele (born January 10, 1964, in Stuttgart, Germany)[1] is a German-born American physical chemist[2] and biophysicist who is currently emeritus James R. Eiszner Chair in Chemistry, Professor of Physics, Professor of Biophysics and Computational Biology at the University of Illinois Urbana-Champaign.[3]

Early life and education

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He was born in Stuttgart, Germany, son of Helmut Grübele and E. A. Victoria Grübele with two younger siblings Andrea and Philip. He attended the Lycée Français in Vienna, Austria, the Colegio ECOS in Marbella, Spain, and Drew School in San Francisco, US as Valedictorian. He completed his B.S in chemistry at the University of California, Berkeley in 1984, with the University Certificate of Distinction and Department Citation for Highest Honors. He was advised by Ken Sauer (biophysics), Wilhelm Maier (organic synthesis), and Richard J. Saykally (laser spectroscopy). He did his graduate work at the University of California, Berkeley in the laboratory of Richard J. Saykally, where he was a University Fellow (1984–1986), IBM Predoctoral Fellow, (1986–1987), and a Dow Chemical Graduate Fellow (1987–1988). Subsequently he held a postdoctoral position with Ahmed Zewail at California Institute of Technology, after which he joined the faculty of the University of Illinois in 1992.[citation needed]

Current positions

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Gruebele, now professor emeritus, was Head of chemistry (2017–2020) and James R. Eiszner Endowed Chair in Chemistry (2008–2024), professor of physics, professor of biophysics and quantitative biology, professor in the Center for Advanced Study, and professor in the Carle-Illinois College of Medicine. He also was a faculty member of the Beckman Institute at the University of Illinois, and was an adjunct professor of physics at Michigan State University to support biological physics faculty mentoring.[citation needed]

Research

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His research covers a wide range of areas in chemical physics and biological physics, including the kinetics of biological systems, quantum dynamics of energy flow within molecules, and optically assisted scanning tunneling microscopy. A common theme of his research is the implementation of state-of-the-art laser and microscopy techniques to interrogate and manipulate complex systems, coupled with quantum or classical simulations. He has published over 300 articles, books and patents on topics ranging from quantum computing, to RNA and protein folding in the test tube and inside cells, to fish swimming behavioral studies,[2] and ultra-distance cycling.

Recent work

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  • Dynamics of fast-folding proteins to make the connection between experiment and physics-based computer simulations of protein folding.[4]
  • FreI (Fast Relaxation Imaging) that combines fluorescence microscopy and fast temperature jump or osmotic pressure jump to study protein dynamics inside living cells and living animals.[5][6]
  • A sub-microsecond pressure jump technique to study fast protein refolding and help guide computer simulations (molecular dynamics) for how proteins fold.[7]
  • With Martina Havenith, Kinetic Terahertz Absorption Spectroscopy elucidating the role of long-range interactions of water with biomolecules.[8]
  • Two-state dynamics recorded on glass surfaces using time-resolved Scanning Tunneling Microscopy, to measure the size and heterogeneous dynamics of cooperatively rearranging regions on a glass.[9]
  • SMA-STM (Single Molecule Absorption detected by Scanning Tunneling Microscopy), a technique that can image excited state orbitals of nanostructures with sub-nanometer position resolution [10] and sub-picosecond time resolution.[11]
  • With Stephen Boppart, non-linear interferometric vibrational imaging which produces easy-to-read, color-coded images of tissue, outlining clear tumor boundaries with more than 99% confidence.[12]
  • Computational and theoretical work in the area of quantum energy flow,[13] quantum computation,[14] and quantum information,[15] as well as fundamental transport theory and computation.[16]

Awards

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Gruebele collaborated with Hanoi University of Science to port the University of Illinois Department of Chemistry undergraduate curriculum for Chemistry to Vietnam.[23] He has been on the list of "Teachers Ranked Excellent by their Students" at Illinois multiple times (most recently 2024),[24] and received the School of Chemical Sciences Teaching Excellence Award.[25] He is a contributor to LibreTexts, which makes open-access textbooks available to students.

Personal

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Gruebele is married to Nancy Makri,[26] who is also a professor of chemistry and physics at University of Illinois at Urbana-Champaign. They have two children, Alexander and Valerie. He has a strong interest in cycling, running, swimming and triathlon[27] and has competed in many long-distance events, such as the 2013 Boston Marathon,[28] the 2016 solo Race Across America,[29] the 2019 Badwater Ultramarathon,[30][31] the 1406 mile DECA 2022 World Championship ultratriathlon,[32] the 10 day non-stop run at "6 Days in the Dome" in 2024,[33] 15-IronmanTM-Distances-in-15-Days at "What is the Limit" Garda Lake in 2024,[34] and the Ironman World Championship.[27] He has written three how-to books on multi-day ultra-distance cycling, ultratriathlon, and ultrarunning.[35]

See also

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Notes

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  1. ^ "Martin Gruebele's CV" (PDF).
  2. ^ a b "Martin Gruebele | Chemistry at Illinois". www.chemistry.illinois.edu.
  3. ^ "THE GRUEBELE GROUP". School of Chemical Sciences at Illinois. 11 July 2022. Retrieved 5 August 2022.
  4. ^ Snow, Christopher D.; Nguyen, Houbi; Pande, Vijay S.; Gruebele, Martin (November 5, 2002). "Absolute comparison of simulated and experimental protein-folding dynamics". Nature. 420 (6911): 102–106. Bibcode:2002Natur.420..102S. doi:10.1038/nature01160. PMID 12422224. S2CID 1061159 – via www.nature.com.
  5. ^ ” Scientists observe protein folding in living cells for the first time” , www.scientificamerican.com, February 28-2010
  6. ^ Feng, R.; Gruebele, M.; Davis, C. M. (2019). "Quantifying protein dynamics and stability in a living organism". Nature Communications. 10 (1): 1179. Bibcode:2019NatCo..10.1179F. doi:10.1038/s41467-019-09088-y. PMC 6414637. PMID 30862837.
  7. ^ Dumont, Charles; Emilsson, Tryggvi; Gruebele, Martin (July 5, 2009). "Reaching the protein folding speed limit with large, sub-microsecond pressure jumps". Nature Methods. 6 (7): 515–519. doi:10.1038/nmeth.1336. PMID 19483692. S2CID 21989071 – via www.nature.com.
  8. ^ ”Water Is 'Designer Fluid' That Helps Proteins Change Shape” , www.sciencedaily.com, Aug. 7-2008
  9. ^ “Researchers record two-state dynamics in glassy silicon” , www.physorg.com, June 14-2011
  10. ^ "Ultrafast nanometric imaging of energy flow within and between single carbon dots".
  11. ^ Yoksoulian, Lois. "Cheap, nontoxic carbon nanodots poised to be quantum dots of the future". news.illinois.edu.
  12. ^ "Nonlinear Interferometric Vibrational Imaging Tissue-imaging Technique", www.imaging-git.com, Nov. 30-2010
  13. ^ Wong, V.; Gruebele, M. (1999). "How Does Vibrational Energy Flow Fill the Molecular State Space?". The Journal of Physical Chemistry A. 103 (49): 10664. Bibcode:1999JPCA..10310664W. doi:10.1021/jp993510s.
  14. ^ Weidinger, Daniel; Gruebele, Martin (2007). "Quantum computation with vibrationally excited polyatomic molecules: Effects of rotation, level structure, and field gradients". Molecular Physics. 105 (13–14): 1999–2008. Bibcode:2007MolPh.105.1999W. doi:10.1080/00268970701504335. S2CID 122494939.
  15. ^ https://journals.aps.org/pra/abstract/10.1103/PhysRevA.105.033322 "Quantum information scrambling in molecules"
  16. ^ Kocherginsky, Nikolai; Gruebele, Martin (2016). "Mechanical approach to chemical transport". Proceedings of the National Academy of Sciences. 113 (40): 11116–11121. Bibcode:2016PNAS..11311116K. doi:10.1073/pnas.1600866113. PMC 5056083. PMID 27647899.
  17. ^ "In 2020, the Hans Neurath Awardee is Professor Martin Gruebele (University of Illinois at Urbana-Champaign)(The Protein Society, 2020)
  18. ^ "Martin Gruebele awarded 2017 Nakanishi Prize" (American Chemical Society, 2017)
  19. ^ "Martin Gruebele has been awarded the 2008 Raymond and Beverly Sackler Prize in the Physical Sciences", 11/20/2008
  20. ^ "U. of I. alumni research scholar Martin Gruebele receives Bessel Prize",5/1/2005
  21. ^ "The Coblentz Award – Molecular Spectroscopy | Coblentz Society".
  22. ^ "CAS Fellows Archive". Center for Advanced Study, University of Illinois at Urbana-Champaign. Archived from the original on 30 June 2018. Retrieved 2 August 2018.
  23. ^ "East-West Partnership", http://cen.acs.org, May 31, 2010
  24. ^ "Teachers Ranked as Excellent". citl.illinois.edu.
  25. ^ "SCS Teaching Award Recipients | School of Chemical Sciences at Illinois". scs.illinois.edu.
  26. ^ "Nancy Makri | Chemistry at Illinois". www.chemistry.illinois.edu.
  27. ^ a b "Wild Card Cycling – Central Illinois Premiere Cycling Team".
  28. ^ "University affiliates recount Boston Marathon bombings". The Daily Illini. 23 April 2013. Retrieved 5 August 2022.
  29. ^ "RESULTS". RAAM2022.
  30. ^ "DUV Ultra Marathon Statistics". statistik.d-u-v.org.
  31. ^ "BADWATER 135 | Badwater".
  32. ^ IUTA DECA 2022 Results
  33. ^ "6 Days in the Dome" results
  34. ^ "What is the Limit" Results
  35. ^ Masters Ultraracing Series
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