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Protein-coding gene in the species Homo sapiens
Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[ 5] [ 6] [ 7] [ 8]
MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID .[ 9]
Clinical significance [ edit ]
MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[ 9]
Variants of the MTCH2 gene may be associated with obesity .[ 10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.[ 9]
^ a b c ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha" . Molecular and Cellular Biology . 25 (11): 4579–90. doi :10.1128/MCB.25.11.4579-4590.2005 . PMC 1140633 . PMID 15899861 .
^ Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". Journal of Bioenergetics and Biomembranes . 37 (3): 113–9. doi :10.1007/s10863-005-6222-3 . PMID 16167168 . S2CID 2395673 .
^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?" . Apoptosis . 12 (5): 869–76. doi :10.1007/s10495-007-0748-2 . PMID 17453157 .
^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, et al. (July 2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers" . PLOS Genetics . 4 (7): e1000129. doi :10.1371/journal.pgen.1000129 . PMC 2444049 . PMID 18636107 .
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^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Human Molecular Genetics . 18 (8): 1489–96. doi :10.1093/hmg/ddp041 . PMC 2664142 . PMID 19164386 .
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