MORC2

MORC2
Identifiers
Aliases	MORC2, ZCW3, ZCWCC1, CMT2Z, MORC family CW-type zinc finger 2, DIGFAN
External IDs	OMIM: 616661; MGI: 1921772; HomoloGene: 8966; GeneCards: MORC2; OMA:MORC2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,968,774 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,640,477 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; ganglionic eminence; ; endothelial cell; ; stromal cell of endometrium; ; saphenous vein; ; ventricular zone; ; testicle; ; gastric mucosa;
	Top expressed in
	tail of embryo; ; genital tubercle; ; superior cervical ganglion; ; hand; ; zygote; ; spermatocyte; ; otolith organ; ; utricle; ; spermatid; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; protein binding; magnesium ion binding; chromatin binding; ATP binding; ATPase activity; protein homodimerization activity; nucleotide binding; hydrolase activity;
Cellular component	nucleus; cytoplasm; cytosol; heterochromatin; nuclear matrix; chromosome;
Biological process	fatty acid metabolic process; lipid metabolism; cellular response to DNA damage stimulus; negative regulation of gene expression, epigenetic; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; positive regulation of DNA methylation-dependent heterochromatin assembly; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	22880
	74522
	ENSG00000133422
	ENSMUSG00000034543
	Q9Y6X9
	Q69ZX6
	NM_001303256; NM_001303257; NM_014941
	NM_001159288; NM_198162; NM_001363202
	NP_001290185; NP_001290186; NP_055756
	NP_001152760; NP_937805; NP_001350131
	Wikidata
View/Edit Human	View/Edit Mouse

MORC family CW-type zinc finger protein 2 is a protein that in humans is encoded by the MORC2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133422 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034543 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.
^ "Entrez Gene: MORC2 MORC family CW-type zinc finger 2".

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133422 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034543 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14607086-5] Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.

[entrez-6] "Entrez Gene: MORC2 MORC family CW-type zinc finger 2".

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References

Further reading