From Wikipedia, the free encyclopedia
Non-coding RNA in the species Homo sapiens
MicroRNA 195 is a microRNA that in humans is encoded by the MIR195 gene .
[ 3]
microRNAs (miRNAs) are short (20-24 nt ) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Flavin RJ, Smyth PC, Laios A, O'Toole SA, Barrett C, Finn SP, Russell S, Ring M, Denning KM, Li J, Aherne ST, Sammarae DA, Aziz NA, Alhadi A, Sheppard BL, Lao K, Sheils OM, O'Leary JJ (February 2009). "Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma" . Mod. Pathol . 22 (2): 197–205. doi :10.1038/modpathol.2008.135 PMID 18677302 . Liu L, Chen L, Xu Y, Li R, Du X (September 2010). "microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells". Biochem. Biophys. Res. Commun . 400 (2): 236–40. doi :10.1016/j.bbrc.2010.08.046 . PMID 20727858 . Gonsalves C, Kalra VK (November 2010). "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195" . J. Immunol . 185 (10): 6253–64. doi :10.4049/jimmunol.1000660 PMID 20952681 . Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L (April 2011). "Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer" . Clin. Cancer Res . 17 (7): 1722–30. doi :10.1158/1078-0432.CCR-10-1800 PMID 21350001 . Wang X, Wang J, Ma H, Zhang J, Zhou X (June 2012). "Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer". Med. Oncol . 29 (2): 919–27. doi :10.1007/s12032-011-9880-5 . PMID 21390519 . S2CID 19566991 . Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N (October 2011). "Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation". J. Cell. Physiol . 226 (10): 2535–42. doi :10.1002/jcp.22598 . PMID 21792910 . S2CID 42464226 . Yang X, Yin J, Yu J, Xiang Q, Liu Y, Tang S, Liao D, Zhu B, Zu X, Tang H, Lei X (January 2012). "miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w" . Oncol. Rep . 27 (1): 250–7. doi :10.3892/or.2011.1472 PMID 21947305 . Brenner B, Hoshen MB, Purim O, David MB, Ashkenazi K, Marshak G, Kundel Y, Brenner R, Morgenstern S, Halpern M, Rosenfeld N, Chajut A, Niv Y, Kushnir M (September 2011). "MicroRNAs as a potential prognostic factor in gastric cancer" . World J. Gastroenterol . 17 (35): 3976–85. doi :10.3748/wjg.v17.i35.3976 PMC 3199555 PMID 22046085 . Zhang QQ, Xu H, Huang MB, Ma LM, Huang QJ, Yao Q, Zhou H, Qu LH (March 2012). "MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion" . Neuro-Oncology . 14 (3): 278–87. doi :10.1093/neuonc/nor216 . PMC 3280801 PMID 22217655 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
