MIMT1

In molecular biology, MER1 repeat containing imprinted transcript 1 (non-protein coding), also known as MIMT1 is a long non-coding RNA. It is an imprinted gene, which is paternally expressed.^[1] Deletion of this gene is lethal in cattle, causing still births and abortions. It is lethal in 85% of individuals with the deletion, it is thought that incomplete silencing of maternally imprinted alleles allows some individuals with the deletion to survive.^[2]

References

^ Kim, J.; Bergmann, A.; Choo, J. H.; Stubbs, L. (2007). "Genomic organization and imprinting of the Peg3 domain in bovine". Genomics. 90 (1): 85–92. doi:10.1016/j.ygeno.2007.03.012. PMID 17509818.
^ Flisikowski, K.; Venhoranta, H.; Nowacka-Woszuk, J.; McKay, S. D.; Flyckt, A.; Taponen, J.; Schnabel, R.; Schwarzenbacher, H.; Szczerbal, I.; Lohi, H.; Fries, R.; Taylor, J. F.; Switonski, M.; Andersson, M. (2010). Roberts, Roland G. (ed.). "A Novel Mutation in the Maternally Imprinted PEG3 Domain Results in a Loss of MIMT1 Expression and Causes Abortions and Stillbirths in Cattle (Bos taurus)". PLOS ONE. 5 (11): e15116. Bibcode:2010PLoSO...515116F. doi:10.1371/journal.pone.0015116. PMC 2994898. PMID 21152099.

[pmid17509818-1] Kim, J.; Bergmann, A.; Choo, J. H.; Stubbs, L. (2007). "Genomic organization and imprinting of the Peg3 domain in bovine". Genomics. 90 (1): 85–92. doi:10.1016/j.ygeno.2007.03.012. PMID 17509818.

[pmid21152099-2] Flisikowski, K.; Venhoranta, H.; Nowacka-Woszuk, J.; McKay, S. D.; Flyckt, A.; Taponen, J.; Schnabel, R.; Schwarzenbacher, H.; Szczerbal, I.; Lohi, H.; Fries, R.; Taylor, J. F.; Switonski, M.; Andersson, M. (2010). Roberts, Roland G. (ed.). "A Novel Mutation in the Maternally Imprinted PEG3 Domain Results in a Loss of MIMT1 Expression and Causes Abortions and Stillbirths in Cattle (Bos taurus)". PLOS ONE. 5 (11): e15116. Bibcode:2010PLoSO...515116F. doi:10.1371/journal.pone.0015116. PMC 2994898. PMID 21152099.

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[2]

See also

References