Lydicamycin

Lydicamycin
Names
	IUPAC name 2-[21-[1-[(2,5-Dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)carbonyl]-1,2,4a,5,6,7,8,8a-octahydro-5,6-dihydroxy-1,3-dimethyl-2-naphthalenyl]-2,6,10,14,18-pentahydroxy-5,11,17,19-tetramethyl-4,8,12,16-heneicosatetraen-1-yl] 1-pyrrolidinecarboximidamide
Identifiers
CAS Number	133352-27-9 ;
3D model (JSmol)	Interactive image;
ChemSpider	59700986;
PubChem CID	54715242;
	InChI InChI=1S/C47H74N4O10/c1-26(37(54)10-7-11-38(55)27(2)13-18-33(53)24-31-9-8-22-51(31)46(48)49)12-16-32(52)17-14-28(3)42(58)29(4)15-19-35-30(5)23-34-36(20-21-39(56)43(34)59)47(35,6)44(60)41-40(57)25-50-45(41)61/h7,10,12-14,16,23,26,29,31-39,42-43,52-56,58-60H,8-9,11,15,17-22,24-25H2,1-6H3,(H3,48,49)(H,50,61)/b10-7+,16-12+,27-13+,28-14+,44-41+/t26?,29?,31?,32?,33?,34-,35-,36-,37?,38?,39-,42?,43+,47+/m1/s1 Key: BCOQUXPMOLQABB-CTAFOSPESA-N;
	SMILES CC1=C[C@@H]2[C@@H](CC[C@H]([C@H]2O)O)[C@@]([C@@H]1CCC(C)C(/C(=C/CC(/C=C/C(C)C(/C=C/CC(/C(=C/CC(CC3CCCN3C(=N)N)O)/C)O)O)O)/C)O)(C)/C(=C\4/C(=O)CNC4=O)/O;
Properties
Chemical formula	C47H74N4O10
Molar mass	855.127 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Lydicamycin is an organic compound with the molecular formula C₄₇H₇₄N₄O₁₀.^[2] Lydicamycin is an antibiotic with activity against Gram-positive bacteria.^[3] The bacteria Streptomyces lydicamycinicus and Streptomyces platensis produces lydicamycin.^[4]^[5]

References

^ "Lydicamycin (CAS 133352-27-9)". www.caymanchem.com.
^ "Lydicamycin | CAS 133352-27-9". www.scbt.com (in German).
^ Hayakawa, Yoichi; Kanamaru, Naoyuki; Shimazu, Akira; Seto, Haruo (1991). "Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity". The Journal of Antibiotics. 44 (3): 282–287. doi:10.7164/antibiotics.44.282. PMID 2026553.
^ Furumai, Tamotsu; Eto, Keitaro; Sasaki, Tomomitsu; Higuchi, Hiroko; Onaka, Hiroyasu; Saito, Noriko; Fujita, Takeshi; Naoki, Hideo; Igarashi, Yasuhiro (25 October 2002). "TPU-0037-A, B, C and D, Novel Lydicamycin Congeners with Anti-MRSA Activity from Streptomyces platensis TP-A0598". The Journal of Antibiotics. 55 (10): 873–880. doi:10.7164/antibiotics.55.873. ISSN 0021-8820. PMID 12523820.
^ Komaki, Hisayuki; Hosoyama, Akira; Igarashi, Yasuhiro; Tamura, Tomohiko (6 March 2020). "Streptomyces lydicamycinicus sp. nov. and Its Secondary Metabolite Biosynthetic Gene Clusters for Polyketide and Nonribosomal Peptide Compounds". Microorganisms. 8 (3): 370. doi:10.3390/microorganisms8030370. PMC 7143880. PMID 32155704.

Linskens, Hans-Ferdinand; Jackson, John F. (6 December 2012). Alkaloids. Springer Science & Business Media. p. 70. ISBN 978-3-642-84226-9.
Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 86. Springer Science & Business Media. 6 December 2012. p. 186. ISBN 978-3-7091-6029-9.
Morelli, Massimiliano; Bahar, Ofir; Papadopoulou, Kalliope K.; Hopkins, Donald L.; Obradović, Aleksa (29 October 2020). Role of Endophytes in Plant Health and Defense Against Pathogens. Frontiers Media SA. p. 75. ISBN 978-2-88966-098-8.
Komaki, Hisayuki; Ichikawa, Natsuko; Hosoyama, Akira; Fujita, Nobuyuki; Igarashi, Yasuhiro (December 2015). "Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins". Standards in Genomic Sciences. 10 (1): 58. doi:10.1186/s40793-015-0046-5. PMC 4572681. PMID 26380643.

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