List of adverse effects of axitinib
This is a list of adverse effects of the anti-cancer drug axitinib, sorted by frequency of occurrence.[1][2][3][4][5][6]
Very common
[edit]Very common (>10% incidence) adverse effects include:
- Underactive thyroid
- Decreased appetite
- Headache
- Dizziness
- Taste changes
- Haemorrhage
- High blood pressure
- Cough
- Shortness of breath
- Speech disorder
- Diarrhoea
- Nausea
- Vomiting
- Abdominal pain
- Stomatitis
- Indigestion
- Hand-foot syndrome
- Dry skin
- Rash
- Joint aches and pains
- Pain in the extremities
- Proteinuria
- Fatigue
- Asthenia
- Mucosal inflammation
- Weight loss
Common
[edit]Common (1–10% incidence) adverse effects include:
- Anaemia
- Thrombocytopenia
- Hyperthyroidism
- TSH-increased
- Dehydration
- High blood potassium
- High blood calcium
- Ringing in the ears
- Venous embolic and thrombotic events
- Arterial embolic and thrombotic events
- Oropharyngeal pain
- Flatulence
- Haemorrhoids
- Glossodynia
- Hyperbilirubinaemia
- Itchiness
- Erythema
- Hair loss
- Myalgia
- Kidney failure
- Increased lipase
- Increases alanine aminotransferase
- Increased amylase
- Increased aspartate aminotransferase
- Increased alkaline phosphatase
- Increased creatinine
Uncommon
[edit]Uncommon (0.1–1% incidence) adverse effects include:
- Gastrointestinal Perforation and fistula
- Reversible posterior leukoencephalopathy syndrome
- Polycythaemia
References
[edit]- ^ "Inlyta (axitinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 25 January 2014.
- ^ "INLYTA (axitinib) tablet, film coated [Pfizer Laboratories Div Pfizer Inc]". DailyMed. Pfizer Laboratories Div Pfizer Inc. September 2013. Retrieved 25 January 2014.
- ^ "Inlyta : EPAR - Product Information" (PDF). European Medicines Agency. Pfizer Ltd. 17 December 2013. Retrieved 25 January 2014.
- ^ "Inlyta 1 mg 3mg, 5 mg & 7mg film-coated tablets - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Pfizer Limited. 5 December 2013. Archived from the original on 22 February 2014. Retrieved 25 January 2014.
- ^ "PRODUCT INFORMATION INLYTA (axitinib)" (PDF). TGA eBusiness Services. Pfizer Australia Pty Ltd. 5 July 2013. Retrieved 25 January 2014.
- ^ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.