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Kim Jae Kyoung

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Not to be confused with Kim Jae-kyung.
Kim Jae Kyoung
Born(1982-12-14)December 14, 1982
Daegu, South Korea
EducationPhD
Alma materUniversity of Michigan, Seoul National University
Scientific career
FieldsMathematical biology, circadian rhythms, sleep, single-cell sequencing, cancer, multi-scale stochastic systems, machine learning, pharmacosytems model
InstitutionsInstitute for Basic Science, KAIST, Korea Institute for Advanced Study, University of Michigan, Mathematical Biosciences Institute
ThesisMathematical Modeling and Analysis of Cellular Clocks (2012)
Doctoral advisorDaniel Forger, Victoria Booth
Other academic advisorsTrachette Jackson
Korean name
Hangul
김재경
Hanja
Revised RomanizationGim Jaegyeong
McCune–ReischauerKim Chaegyŏng
WebsiteIBS Biomedical Mathematics Group
Lab at KAIST

Kim Jae Kyoung (Korean: 김재경; born December 14, 1982) is a biomedical mathematician and associate professor at KAIST in the Department of Mathematical Sciences[1][2] and a chief investigator in the Pioneer Research Center for Mathematical and Computational Sciences at the Institute for Basic Science. His research focuses on mathematical biology and medicine, specifically the combination of nonlinear dynamics, the theory of stochastic processes, and computational science, to better understand disease mechanisms and develop relevant treatment strategies, including drug and digital medicine for sleep disorders.[3][4]

Education

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Kim was born in Daegu, South Korea in 1982. He attended Yeungnam Middle School and Yeungnam High School before moving to Seoul where he graduated summa cum laude with a B.A. in mathematics education from Seoul National University in 2005. Upon reading a news article about using math to study heart disease, it lead him to the University of Michigan as it was known for mathematical biology.[5] He received his Ph.D. in applied and interdisciplinary mathematics in 2013. He received the Sumner Byron Myers Prize for this thesis on cellular clocks.[6][7] His advisors were Daniel Forger and Victoria Booth while Trachette Jackson was a thesis committee member.

Career

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Kim was a postdoctoral fellow at the Mathematical Biosciences Institute within Ohio State University.[8][9][10] Returning to Korea, he served as an assistant[11] and associate professor in the Department of Mathematical Science in KAIST.[12] He also worked as an associate member at the Korea Institute for Advanced Study from 2018 and then as a visiting scholar in the Department of Mathematics in the University of Michigan from 2019 to 2020. He became a member of Young Korean Academy of Science and Technology in 2019.[13]

In March 2021, Kim became a chief investigator of the Pioneer Research Center for Mathematical and Computational Sciences at the Institute for Basic Science (IBS), heading the Biomedical Mathematics Group (BIMAG).[14][15][16] Three teams conduct research at BIMAG. The Intracellular Dynamics Team develops reduction methods for multi-scale stochastic systems and identifies molecular mechanisms underlying robust circadian rhythms. The Intercellular Dynamics Team develops inference methods for dynamic networks and causes of and treatment strategies for circadian rhythm sleep disorders at the network level. The Systemic Dynamics Team develops methods for analyzing noisy human activity data from wearable devices and their application to identify optimal sleep patterns, and develops chronotherapy for sleep disorders and cancer.[17]

Mechanisms for period regulation of circadian clock

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Despite temperature changes, Kim found a mathematical model which underlies a molecular mechanism for regulation of the circadian clock. This biological clock was discovered in 1954, but the method for how it operates took more than 60 years to understand. Relevant factors include the topology of biochemical network underlying the circadian clock, phospho-switch that controls stability of key repressor proteins can compensate the effects of temperature, cells in the mammalian circadian clocks are coupled to generate synchronized rhythms, and a mechanism that filters stochasticity in the circadian clock.[18][19]

Mathematical models to treat diseases caused by disrupted circadian rhythms

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Misalignment of circadian rhythms with the external environment can cause significant physiological problems. Kim studied the drug PF-670462 which aims to realign the circadian clock. Using pharmacokinetic data, he built a pharmacology model and analyzed the phase response curve to the drug and light which helped to predict the drug's effect under various environmental conditions.[20] As disruption of circadian rhythms increases the risk of getting cancer, he studied the interactions between p53 and PER2.[21]

Derivation of validity condition for stochastic QSSA

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Kim was the first to propose and then prove multiple results in justifying the stochastic quasi-steady state approximation (QSSA).[22][23][24][25][26] The approximation has been widely used to reduce stochastic model of various biological systems.[27] Despite its common use, there has been a critical problem in understanding whether the stochastic QSSA is accurate and under what conditions it may fail. Kim has worked to developing a method to compute the error of the stochastic QSSA directly. This provided a clear guideline for when and how to use the stochastic QSSA. Furthermore, he developed a new method for simplifying models when the stochastic QSSA is invalid.[28][26]

Discovering and correcting the error in the equation of FDA guidelines

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Kim found errors in the US Food and Drug Administration's (FDA) current guidance for predicting how drugs interact in the body and created a more accurate formula. The current FDA method is inaccurate, requiring artificial adjustments. The new formula is based on an improved mathematical foundation and can accurately predict drug metabolism rates without artificial factors. When tested, the new formula predicted drug interactions accurately 80% of the time compared to 38% with the equation in FDA guidance. This improvement could greatly enhance drug development and safety in clinical use.[29][30][31]

Software development

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BIMAG has also made various software during their research, including mathematical models for biological oscillators, Bayesian inference algorithms, stochastic analysis, causality inference, diagnosis for sleep disorders, and sleep data imputation.[32]

Journal editing

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Jae Kyoung has been an editorial board member of Journal of Biological Rhythms,[33] PLOS One,[34] Journal of Theoretical Biology,[35] Mathematical Biosciences,[36] Current Opinion in Systems Biology,[37] npj Systems Biology and Applications,[38] and npj Biological Timing and Sleep,[39] as well as a guest associate editor of PLOS Computational Biology.[40]

Awards and honors

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Scientific societies and committees

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Selected publications

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See also

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References

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  1. ^ "김재경: KAIST 수리과학과 부교수". Horizon (in Korean). Korea Institute for Advanced Study. Retrieved 11 January 2024.
  2. ^ "고등과학원 허준이 수학난제연구소 대중강연 시리즈". Korea Institute for Advanced Study (in Korean). Retrieved 11 January 2024.
  3. ^ "A New IBS Center in Mathematical Biology Kicks Off". Institute for Basic Science. 11 March 2021. Retrieved 19 March 2021.
  4. ^ Gen Kurosawa (17 November 2021). "iTHEMS Biology Seminar by Dr. Jae Kyoung Kim on November 11, 2021". Interdisciplinary Theoretical and Mathematical Sciences Program. RIKEN. Retrieved 11 January 2024.
  5. ^ "[주말N수학] 생명의 비밀 파헤치는 수학의 세계". Donga Science (in Korean). 10 July 2021. Retrieved 17 January 2024.
  6. ^ a b "Department Awards". LSA Mathematics. University of Michigan. Retrieved 29 August 2022.
  7. ^ a b "ContinuUM" (PDF). Department of Mathematics. University of Michigan. 2014. Retrieved 29 September 2022.
  8. ^ "Weekly Mathematical Biology Seminar". Department of Mathematics. University of Utah. 2015. Retrieved 29 August 2022.
  9. ^ "Biomathematics Seminar". Department of Mathematics. Florida State University. Retrieved 29 August 2022.
  10. ^ "Daniel B. Forger III" (PDF). University of Michigan. Retrieved 29 August 2022.
  11. ^ "KAIST's mathematician reveals the mechanism for sustaining biological rhythms". American Association for the Advancement of Science#EurekAlert!. 28 August 2015. Retrieved 11 January 2024.
  12. ^ "김재경 교수, 올해의 최석정상 수상". Department of Mathematical Sciences (in Korean). KAIST. 30 November 2021. Retrieved 11 January 2024.
  13. ^ a b "회원소개" (in Korean). Retrieved 11 October 2022.
  14. ^ 최소라 (26 February 2021). "IBS 수리·계산과학연구단 의생명 수학 그룹 출범". YTN Science (in Korean). YTN. Retrieved 19 March 2021.
  15. ^ 고재원 (26 February 2021). "생물학 난제 수학적 관점에서 푼다…IBS 신규연구그룹 출범" (in Korean). Donga Science. Retrieved 17 January 2024.
  16. ^ "수리생물학으로 수면질환 치료법 찾는다…IBS '의생명 수학그룹' 출범" (in Korean). Herald Corporation. 26 February 2021. Retrieved 17 January 2024.
  17. ^ "Research Aim". IBS Biomedical Mathematics Group. Institute for Basic Science. Retrieved 11 January 2024.
  18. ^ "Korean researcher solves 60-year-old puzzle of biological clock through math". The Dong-a Ilbo. 6 October 2015. Retrieved 17 January 2024.
  19. ^ "Professor Jae Kyoung Kim Receives the 2017 HSFP Award". KAIST. 21 July 2017. Retrieved 30 November 2023.
  20. ^ "Professor Jae Kyoung Kim to Lead a New Mathematical Biology Research Group at IBS". News. KAIST. 18 March 2021. Retrieved 17 January 2024.
  21. ^ Gotoh, Tetsuya; Kim, Jae Kyoung; Liu, Jingjing; Finkielstein, Carla V. (9 November 2016). "Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2". PNAS. 113 (47): 3516–13521. Bibcode:2016PNAS..11313516G. doi:10.1073/pnas.1607984113. PMC 5127372. PMID 27834218.
  22. ^ Kim, Jae Kyoung; Josic, Kresimir; Bennett, Matthew R. (5 August 2014). "The Validity of Quasi-Steady-State Approximations in Discrete Stochastic Simulations". Biophysical Journal. 107 (3): 783–793. arXiv:1406.2244. Bibcode:2014BpJ...107..783K. doi:10.1016/j.bpj.2014.06.012. PMC 4129492. PMID 25099817.
  23. ^ Kim, Jae Kyoung; Josić, Krešimir; Bennett, Matthew R. (23 November 2015). "The relationship between stochastic and deterministic quasi-steady state approximations". BMC Systems Biology. 9: 87. doi:10.1186/s12918-015-0218-3. PMC 4657384. PMID 26597159.
  24. ^ Kim, Jae Kyoung; Rempala, Grzegorz; Kang, Hye-Won (12 October 2017). "Reduction for Stochastic Biochemical Reaction Networks with Multiscale Conservations". Multiscale Modeling & Simulation. 15 (4): 1376–1403. arXiv:1704.05628. doi:10.1137/16M1099443. S2CID 7497139.
  25. ^ Kim, Jae Kyoung; Sontag, Eduardo D. (5 June 2017). "Reduction of multiscale stochastic biochemical reaction networks using exact moment derivation". PLOS Computational Biology. 13 (6): e1005571. Bibcode:2017PLSCB..13E5571K. doi:10.1371/journal.pcbi.1005571. PMC 5481150. PMID 28582397.
  26. ^ a b Song, Yun Min; Hong, Hyukpyo; Kim, Jae Kyoung (18 October 2018). "Universally valid reduction of multiscale stochastic biochemical systems using simple non-elementary propensities". PLOS Computational Biology. 17 (10): e1008952. doi:10.1371/journal.pcbi.1008952. PMC 8562860. PMID 34662330.
  27. ^ "An Estimation Method for Enzyme Kinetic Model Parameters Based on Bayesian Approach". JSM 2018. American Statistical Association. 31 July 2018. Retrieved 6 February 2024.
  28. ^ "The relationship between deterministic and stochastic quasi-steady-state approximations". Korean Mathematical Society. Retrieved 6 February 2024.
  29. ^ "Scientists re-writes FDA-recommended equation to improve estimation of drug-drug interaction". KAIST. 18 January 2023. Retrieved 29 January 2024.
  30. ^ Kim Jae Kyoung (11 January 2023). "[헤럴드광장] 수학이 생명에 필요한 순간" (in Korean). Herald Corporation. Retrieved 29 January 2024.
  31. ^ ""美 FDA보다 더 정확" 韓 연구진, 약물 상호작용 예측 수식 개발". 헤럴드경제 (in Korean). 4 January 2023. Retrieved 6 February 2024.
  32. ^ "Software". IBS Biomedical Mathematics Group. Institute for Basic Science. Retrieved 11 January 2024.
  33. ^ "Editorial Board". Journal of Biological Rhythms. SAGE Publishing. 28 October 2015. Retrieved 29 August 2022.
  34. ^ "Editorial Board". PLOS One. Retrieved 29 August 2022.
  35. ^ "Editorial board". Science Direct. Elsevier. Retrieved 11 January 2024.
  36. ^ "Editorial board". ScienceDirect (in Korean). Elsevier. Retrieved 11 January 2024.
  37. ^ "Editorial board". ScienceDirect (in Korean). Retrieved 11 January 2024.
  38. ^ "About the Editors". npj Systems Biology and Applications. Retrieved 6 February 2024.
  39. ^ "About the Editors". npj Biological Timing and Sleep. Retrieved 6 February 2024.
  40. ^ "PLOS Computational Biology 2014 Reviewer Thank You" (PDF). PLOS Computational Biology. 27 February 2015. doi:10.1371/journal.pcbi.1004184.s001. Retrieved 29 September 2022.
  41. ^ "CI Jae Kyoung Kim received the Citation from the Minster Ministry of Science and ICT. CI 김재경 교수님께서 과학기술정보통신부 장관으로부터 표창을 받았습니다". IBS Biomedical Mathematics Group. Institute for Basic Science. 1 November 2023. Retrieved 11 January 2024.
  42. ^ "김재경 교수, 과학기술정보통신부 장관 표창 받아". Department of Mathematical Sciences (in Korean). KAIST. 1 November 2023. Retrieved 11 January 2024.
  43. ^ "김재경 교수, KAIST 글로벌 연구 협력상 수상해". Depatment of Mathematical Sciences (in Korean). KAIST. 12 December 2023. Retrieved 11 January 2024.
  44. ^ 이진영 (25 November 2021). "'2021 최석정상' 수상자 김재경·임선희·송홍엽 교수…수학계 기여". Newsis. Retrieved 29 September 2022.
  45. ^ Kim Jae Kyoung (26 November 2021). '올해의 최석정상' 김재경·임선희·송홍엽 씨 선정 / YTN 사이언스 (News) (in Korean). Newsis. Retrieved 29 September 2022.
  46. ^ "CI Jae Kyoung Kim won '올해의 최석정상.' Congratulation!". Biomedical Mathematics Group. Institute for Basic Science. Retrieved 29 September 2022. '올해의 최석정상' (Choi Seok-jeong award in this year) is named after Choi, Seok-jeong who was a Korean politician and mathematician in the Joseon period of Korea. This award was established 2021 to give mathematicians credit for developing and applying mathematics or spreading mathematics culture.
  47. ^ "2021년 올해의 최석정상, 한국과학기술원 김재경 교수, 서울대학교 임선희 교수, 연세대학교 송홍엽 교수 선정". Korean Mathematical Society (in Korean). 29 November 2021. Retrieved 7 October 2022.
  48. ^ "J. Shelton Horsley Research Award Past Recipients". Virginia Academy of Science. Retrieved 29 September 2022.
  49. ^ "Professor Jae Kyoung Kim Receives the 2017 Human Frontier Science Program Award". Department of Mathematical Sciences (in Korean). KAIST. 10 June 2017. Retrieved 11 January 2024.
  50. ^ "Professor Jae-Kyoung Kim Is Named as the Young Researcher of the Year by the Korean Society for Industrial and Applied Mathematics". Mathematical Sciences. KAIST. 8 November 2017. Retrieved 29 September 2022.
  51. ^ "수상". Korean Society for Industrial and Applied Mathematics (in Korean). Retrieved 7 October 2022.
  52. ^ "김재경 교수, 노벨상 펀드 지원 대상자 선정". KAIST (in Korean). 22 March 2017. Retrieved 29 September 2022.
  53. ^ "Teaching". Dept. of Mathematical Sciences. KAIST. Retrieved 29 September 2022.
  54. ^ 유덕영 (24 November 2016). "이 젊은 과학자들, 대한민국의 미래를 연다". Dong-a Ilbo (in Korean). Retrieved 7 October 2022.
  55. ^ "포스코청암재단, 청암 사이언스(Science) 펠로 31명에게 증서 수여". POSCO Newsroom (in Korean). POSCO. 18 September 2015. Retrieved 11 January 2024.
  56. ^ "올해의 펠로". POSCO TJ Park Foundation (in Korean). Archived from the original on 29 September 2022. Retrieved 29 September 2022.
  57. ^ "김재경 교수, 2015년도 대한수학회 상산젊은수학자상 수상". Department of Mathematical Sciences (in Korean). 3 November 2015. Retrieved 29 September 2022.
  58. ^ "역대 학회상 수상자". Korean Mathematical Society (in Korean). Retrieved 29 September 2022.
  59. ^ "Department Awards". Department of Mathematics. University of Michigan. Retrieved 29 September 2022.
  60. ^ "Rackham Awards". LSA Mathematics. University of Michigan. Retrieved 7 October 2022.
  61. ^ "Committees". Society for Research on Biological Rhythms. Retrieved 29 September 2022.
  62. ^ "Conference Information". SMB2021. Society for Mathematical Biology. Retrieved 29 September 2022.
  63. ^ "국제교류위원회". 한국산업응용수학회 (in Korean). Retrieved 7 October 2022.
  64. ^ "Steering Committee". Population Approach Group in Korea (in Korean). Retrieved 7 October 2022.
  65. ^ "2021-2022 KSIAM 이사회". 한국산업응용수학회 (in Korean). Retrieved 7 October 2022.
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