Jump to content

Kelly's ZnS

From Wikipedia, the free encyclopedia

Kelly's is a test statistic that can be used to test a genetic region for deviations from the neutral model, based on the squared correlation of allelic identity between loci.[1]

Details

[edit]

Given loci and , the Linkage Disequilibrium between these loci, is denoted as

where is the frequency of the alternative allele at i and j co-occurring and and the frequency of the alternative allele at and respectively.

a standardised measure of this is the squared correlation of allelic identity between loci and [2]

Where averages over all pairwise combinations between S loci.

Usage

[edit]

Inflated scores indicate a deviation from the neutral model and can be used as a potential signature of previous selection

References

[edit]
  1. ^ Kelly, J. K. (July 1997). "A test of neutrality based on interlocus associations". Genetics. 146 (3): 1197–1206. doi:10.1093/genetics/146.3.1197. ISSN 0016-6731. PMC 1208047. PMID 9215920.
  2. ^ Hartl, Daniel L. (1989). Principles of population genetics. Andrew G. Clark (2nd ed.). Sunderland, Mass.: Sinauer Associates. ISBN 0-87893-302-6. OCLC 18558351.