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Kazushige Touhara

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Kazushige Touhara
Born
Japan
NationalityJapanese
Alma materThe University of Tokyo
Known forOlfaction,Pheromone,Taste,Neuroscience
Scientific career
FieldsChemoreception
InstitutionsThe University of Tokyo
Doctoral advisorGlenn D. Prestwich
Other academic advisorsRobert Lefkowitz

Kazushige Touhara (ja: 東原 和成) is a Japanese biologist, neuroscientist, and a professor at the University of Tokyo, Japan.

After training in the field of organic chemistry,[1] insect endocrinology,[2] and GPCR signaling,[3] he began to establish his team to conducted research on chemoreception with support from Hiroshi Kataoka.[4]

In 2024, he serves as the head of the Union of Japanese Societies for Biological Science and is involved in initiatives such as advocating for the doubling of Japan's scientific research funding.[5] Additionally, he has published several essays focused on improving education and scientific research in Japan.[6][7]

Research

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Plants

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  • Discovery that transcriptional regulatory factors are involved in plant chemical sensing.[8][9]

Insects

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Mammals

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  • Functional characterization of an olfactory receptor expressed in olfactory neurons.[13]
  • Functional characterization of an olfactory receptor expressed in tissues other than olfactory neurons.[14]
  • Detection of olfactory signals in vitro.[15]
  • Identification of a natural ligand of an olfactory receptor.[16]
  • Identification of a musk olfactory receptor.[17]
  • Discovery of tears as a pheromone source.[18][19][20][21][22]
  • Discovery of blood as a chemosensory cue.[23]

Human

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  • Clarification of the spatiotemporal dynamics of odor representations in the brain.[24]

Awards and honors

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  • Frank Allison Linville's RH Wright Award in Olfactory Research (2006)
  • Japan Academy Medal (2009)
  • Kunio Yamazaki Distinguished Lectureship Award (2017)

Early life

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He was well known as a tennis player at his university during his college years.[25] It is said that he once aspired to be an actor.[26]

Career

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Just before he was hired as an associate professor at the University of Tokyo, Nature published an article addressing concerns about the employment of younger researchers.[27]

References

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  1. ^ Kitahara, Takeshi; Touhara, Kazushige; Watanabe, Hidenori; Mori, Kenji (1989). "Stereocontrolled synthesis of both the enantiomers of phaseic acid and its methyl ester, a pivotal metabolite of abscisic acid". Tetrahedron. 45 (20): 6387–6400. doi:10.1016/S0040-4020(01)89516-8.
  2. ^ 東原, 和成 (1994). "昆虫の成長・変態を制御するしくみ" (in Japanese). doi:10.1271/kagakutoseibutsu1962.32.13.
  3. ^ "膜受容体の存在の実証から結晶構造の解明まで" (in Japanese). 2012: 羊土社（実験医学2012年12月号 www.yodosha.co.jp/yodobook/book/9784758100908/）.{{cite web}}: CS1 maint: location (link)
  4. ^ "とことん論理的に考え、魂を注ぎこんだときにブレークスルーが生まれる" (PDF). NATURE DIGEST (in Japanese). 2005.
  5. ^ Ikarashi, Anna (2024-07-04). "Japan's scientists demand more money for basic science". Nature. doi:10.1038/d41586-024-00942-8. ISSN 0028-0836. PMID 38961217.
  6. ^ 東原, 和成. "サイエンスにおける私にとっての日本語 「蛋白質・核酸・酵素」2006年10月号５０周年記念号" (in Japanese).
  7. ^ "巻頭言 日本味と匂学会誌 Vol.31 No.1 PP.1-2 2024 年 5 月" (PDF) (in Japanese).
  8. ^ Nagashima, Ayumi; Higaki, Takumi; Koeduka, Takao; Ishigami, Ken; Hosokawa, Satoko; Watanabe, Hidenori; Matsui, Kenji; Hasezawa, Seiichiro; Touhara, Kazushige (2019-02-15). "Transcriptional regulators involved in responses to volatile organic compounds in plants". Journal of Biological Chemistry. 294 (7): 2256–2266. doi:10.1074/jbc.RA118.005843. PMC 6378981. PMID 30593507.
  9. ^ "I smell a winner: Linking plant olfactory stimuli to genetic regulation". www.asbmb.org. Retrieved 2024-08-27.
  10. ^ Nakagawa, Takao; Sakurai, Takeshi; Nishioka, Takaaki; Touhara, Kazushige (2005-03-11). "Insect Sex-Pheromone Signals Mediated by Specific Combinations of Olfactory Receptors". Science. 307 (5715): 1638–1642. Bibcode:2005Sci...307.1638N. doi:10.1126/science.1106267. ISSN 0036-8075. PMID 15692016.
  11. ^ Sato, Koji; Pellegrino, Maurizio; Nakagawa, Takao; Nakagawa, Tatsuro; Vosshall, Leslie B.; Touhara, Kazushige (2008-04-13). "Insect olfactory receptors are heteromeric ligand-gated ion channels". Nature. 452 (7190): 1002–1006. Bibcode:2008Natur.452.1002S. doi:10.1038/nature06850. ISSN 0028-0836. PMID 18408712.
  12. ^ Sato, Koji; Tanaka, Kana; Touhara, Kazushige (2011-07-12). "Sugar-regulated cation channel formed by an insect gustatory receptor". Proceedings of the National Academy of Sciences. 108 (28): 11680–11685. Bibcode:2011PNAS..10811680S. doi:10.1073/pnas.1019622108. ISSN 0027-8424. PMC 3136286. PMID 21709218.
  13. ^ Touhara, Kazushige; Sengoku, Shintaro; Inaki, Koichiro; Tsuboi, Akio; Hirono, Junzo; Sato, Takaaki; Sakano, Hitoshi; Haga, Tatsuya (1999-03-30). "Functional identification and reconstitution of an odorant receptor in single olfactory neurons". Proceedings of the National Academy of Sciences. 96 (7): 4040–4045. Bibcode:1999PNAS...96.4040T. doi:10.1073/pnas.96.7.4040. ISSN 0027-8424. PMC 22416. PMID 10097159.
  14. ^ Fukuda, Nanaho; Yomogida, Kentaro; Okabe, Masaru; Touhara, Kazushige (2004-11-15). "Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility". Journal of Cell Science. 117 (24): 5835–5845. doi:10.1242/jcs.01507. ISSN 1477-9137. PMID 15522887.
  15. ^ Kajiya, Kentaro; Inaki, Koichiro; Tanaka, Motonari; Haga, Tatsuya; Kataoka, Hiroshi; Touhara, Kazushige (2001-08-15). "Molecular Bases of Odor Discrimination: Reconstitution of Olfactory Receptors that Recognize Overlapping Sets of Odorants". The Journal of Neuroscience. 21 (16): 6018–6025. doi:10.1523/JNEUROSCI.21-16-06018.2001. ISSN 0270-6474. PMC 6763140. PMID 11487625.
  16. ^ Yoshikawa, Keiichi; Nakagawa, Hiroaki; Mori, Naoki; Watanabe, Hidenori; Touhara, Kazushige (2013-01-13). "An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor". Nature Chemical Biology. 9 (3): 160–162. doi:10.1038/nchembio.1164. ISSN 1552-4450. PMID 23314914.
  17. ^ Shirasu, Mika; Yoshikawa, Keiichi; Takai, Yoshiki; Nakashima, Ai; Takeuchi, Haruki; Sakano, Hitoshi; Touhara, Kazushige (2014-01-08). "Olfactory Receptor and Neural Pathway Responsible for Highly Selective Sensing of Musk Odors". Neuron. 81 (1): 165–178. doi:10.1016/j.neuron.2013.10.021. PMID 24361078.
  18. ^ Kimoto, Hiroko; Haga, Sachiko; Sato, Koji; Touhara, Kazushige (2005-10-06). "Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons". Nature. 437 (7060): 898–901. Bibcode:2005Natur.437..898K. doi:10.1038/nature04033. ISSN 0028-0836. PMID 16208374.
  19. ^ "Kazushige Touhara". Nature. 437 (7060): xiii. 2005-10-05. doi:10.1038/7060xiiia. ISSN 0028-0836.
  20. ^ Haga, Sachiko; Hattori, Tatsuya; Sato, Toru; Sato, Koji; Matsuda, Soichiro; Kobayakawa, Reiko; Sakano, Hitoshi; Yoshihara, Yoshihiro; Kikusui, Takefumi; Touhara, Kazushige (2010-07-01). "The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor". Nature. 466 (7302): 118–122. Bibcode:2010Natur.466..118H. doi:10.1038/nature09142. ISSN 0028-0836. PMID 20596023.
  21. ^ Ishii, Kentaro K.; Osakada, Takuya; Mori, Hiromi; Miyasaka, Nobuhiko; Yoshihara, Yoshihiro; Miyamichi, Kazunari; Touhara, Kazushige (2017-07-05). "A Labeled-Line Neural Circuit for Pheromone-Mediated Sexual Behaviors in Mice". Neuron. 95 (1): 123–137.e8. doi:10.1016/j.neuron.2017.05.038. PMID 28648498.
  22. ^ Tsunoda, Mai; Miyamichi, Kazunari; Eguchi, Ryo; Sakuma, Yasuo; Yoshihara, Yoshihiro; Kikusui, Takefumi; Kuwahara, Masayoshi; Touhara, Kazushige (2018-04-23). "Identification of an Intra- and Inter-specific Tear Protein Signal in Rodents". Current Biology. 28 (8): 1213–1223.e6. Bibcode:2018CBio...28E1213T. doi:10.1016/j.cub.2018.02.060. PMID 29606417.
  23. ^ Osakada, Takuya; Abe, Takayuki; Itakura, Takumi; Mori, Hiromi; Ishii, Kentaro K.; Eguchi, Ryo; Murata, Ken; Saito, Kosuke; Haga-Yamanaka, Sachiko; Kimoto, Hiroko; Yoshihara, Yoshihiro; Miyamichi, Kazunari; Touhara, Kazushige (2022-02-03). "Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system". Nature Communications. 13 (1): 556. Bibcode:2022NatCo..13..556O. doi:10.1038/s41467-022-28118-w. ISSN 2041-1723. PMC 8814178. PMID 35115521.
  24. ^ Kato, Mugihiko; Okumura, Toshiki; Tsubo, Yasuhiro; Honda, Junya; Sugiyama, Masashi; Touhara, Kazushige; Okamoto, Masako (2022-05-24). "Spatiotemporal dynamics of odor representations in the human brain revealed by EEG decoding". Proceedings of the National Academy of Sciences. 119 (21): e2114966119. Bibcode:2022PNAS..11914966K. doi:10.1073/pnas.2114966119. ISSN 0027-8424. PMC 9173780. PMID 35584113.
  25. ^ "おもしろ研究室". TOUDAI TLO (in Japanese). Archived from the original on 2008-02-19.
  26. ^ 岡勇輝 (2019). "私のメンター 東原和成―化学感覚の真理を嗅ぎ分ける探究者". 実験医学 (in Japanese). 37 (4). ISBN 978-4-7581-2517-8.
  27. ^ Saegusa, Asako (1998-04-02). "Tokyo's plan for new campus under threat". Nature. 392 (6675): 429. Bibcode:1998Natur.392..429S. doi:10.1038/32991. ISSN 0028-0836.
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