KIRREL2

KIRREL2
Identifiers
Aliases	KIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDs	OMIM: 607762; MGI: 2442334; HomoloGene: 35249; GeneCards: KIRREL2; OMA:KIRREL2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,867,136 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,157,115 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; retinal pigment epithelium; ; prefrontal cortex; ; external globus pallidus; ; lymph node; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; white matter of cerebellum; ; respiratory epithelium; ; striatum of neuraxis; ; islet of Langerhans; ; spinal cord; ; nasal epithelium; ; rhombic lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	integral component of membrane; slit diaphragm; membrane; plasma membrane; cell-cell junction;
Biological process	negative regulation of protein phosphorylation; cell adhesion; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	84063
	243911
	ENSG00000126259
	ENSMUSG00000036915
	Q6UWL6
	Q7TSU7
	NM_032123; NM_199179; NM_199180; NM_001329530; NM_001363667
	NM_172898
	NP_001316459; NP_115499; NP_954648; NP_954649; NP_001350596
	NP_766486
	Wikidata
View/Edit Human	View/Edit Mouse

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.^[5]^[6]^[7] It is primarily expressed in β cells of the pancreatic islets.^[5]

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036915 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
^ Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
^ "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999. S2CID 30494486.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126259 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036915 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12837264-5] Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.

[pmid12504092-6] Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.

[entrez-7] "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".

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References

Further reading