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KIF18A

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KIF18A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIF18A, MS-PPP1R99, kinesin family member 18A
External IDsOMIM: 611271; MGI: 2446977; HomoloGene: 41820; GeneCards: KIF18A; OMA:KIF18A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031217

NM_139303

RefSeq (protein)

NP_112494

NP_647464

Location (UCSC)Chr 11: 28.02 – 28.11 MbChr 2: 109.11 – 109.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.[5][6] It is part of the kinesin family of motor proteins.

Function

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KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121621Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027115Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: KIF18A kinesin family member 18A".
  7. ^ Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU (March 2007). "The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression". Current Biology. 17 (6): 488–498. Bibcode:2007CBio...17..488M. doi:10.1016/j.cub.2007.02.036. ISSN 0960-9822. PMID 17346968.

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF18A