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Protein-coding gene in the species Homo sapiens
Potassium channel regulator , also known as KCNRG , is a protein which in humans is encoded by theKCNRG gene .[ 5] [ 6]
KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K+ channels and inhibits their function.[ 5]
Clinical significance [ edit ] KCNRG has been found to be predominantly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent.
Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000198553 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046168 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: KCNRG potassium channel regulator" .^ Ivanov DV, Tyazhelova TV, Lemonnier L, Kononenko N, Pestova AA, Nikitin EA, Prevarskaya N, Skryma R, Panchin YV, Yankovsky NK, Baranova AV (March 2003). "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3" . FEBS Lett . 539 (1–3): 156–60. doi :10.1016/S0014-5793(03)00211-4 PMID 12650944 . ^ Alimohammadi M, Dubois N, Sköldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, Pontén F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, Kämpe O, Carel JC (February 2009). "Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen" . Proc. Natl. Acad. Sci. U.S.A . 106 (11): 4396–401. Bibcode :2009PNAS..106.4396A . doi :10.1073/pnas.0809986106 PMC 2648890 PMID 19251657 .
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