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Justin Stebbing

Justin Stebbing is a British clinician-scientist specialising in oncology and cancer research. He is a professor of biomedical sciences at Anglia Ruskin University[1] and practices with the private sector Phoenix Hospital Group in London.[2]

Stebbing is co-Editor-in-Chief of the journal Oncogene.[3] He is also a visiting professor of cancer medicine and oncology at Imperial College London.[4]

Early life and education

Stebbing graduated from Trinity College, Oxford.[citation needed] After completion of junior doctor positions in Oxford, he trained on the residency programme at The Johns Hopkins Hospital in the US, returning to London to continue his career at The Royal Marsden and then St Bartholomew's Hospitals. His PhD research investigated the interplay between the immune system and cancer including the role of viruses.[5][6] In 2007, he was appointed a senior lecturer, and then in 2009 a full professor, at Imperial College London.[7] In 2011, the National Institute for Health and Care Research awarded Stebbing its first Translational Professorship in Oncology, working on overcoming treatment resistance and targeted precision medicine approaches.[8]

Research career

Stebbing has published over 700 peer-reviewed papers[9] and has an h-index of 89 according to Google Scholar.[10]

Cancer research

Stebbing was an oncology professor at Imperial College London[11] and has gained a reputation for innovative treatments.[12]

He is co-Editor-in-Chief of the journal Oncogene.[13]

The charity Action Against Cancer was set up to support Stebbing's work.[14][failed verification]

Stebbing's research in cancer has included work on the molecular biology of solid tumours. His group identified LMTK3 as an oncogene and therapeutic target in breast cancer.[15] The team characterised the network of microRNAs induced by the estrogen receptor.[16]

Stebbing has also worked on cancers caused by HIV and AIDS, including investigating immune reconstitution inflammatory syndrome in patients with Kaposi's Sarcoma.[17]

He has undertaken extensive work on biosimilars,[18][failed verification] cheaper versions of expensive biologic drugs designed to democratise access to these.[19]

COVID-19

During the Covid-19 pandemic in early 2020, Stebbing used artificial intelligence to identify baricitinib as a potential drug treatment.[20][21] He led studies that showed that the drug reduced mortality in COVID-19 hospitalised patients with pneumonia, which led to the drug being authorised by the US Food and Drug Administration in October 2020 as an Emergency Use Authorization at first in combination with remdesivir, then alone.[22] Stebbing wrote a book, Witness to COVID, 2020, describing its discovery, trials, studies and approval.[23]

Stebbing is part of a team that ran a phase 1/2 clinical trial using invariant natural killer T cells as an 'off-the-shelf' therapy in ventilated patients with acute respiratory distress syndrome (ARDS), the first time these cells have been used in the clinic.[24][25]

Other research

Stebbing has worked on neurological therapies for patients with unmet medical needs who are treatment resistant or unresponsive to other existing medications.[26]

Clinical practice

Stebbing is a Fellow of the Royal College of Physicians,[7] the American Society for Clinical Investigation[27] and the Royal College of Pathologists.[7]

As a clinician-scientist at Imperial College London, Stebbing practiced with the Imperial College Healthcare NHS Trust at Charing Cross Hospital and Hammersmith Hospital.[7] He resigned his permanent position at Imperial in March 2022.[7]

He has also practiced privately in Harley Street.[28] Patients who experienced successful treatments in his care included Michael Parkinson and Lynda Bellingham.[11]

As of 2024, he practices with the private Phoenix Hospital Group, where he specialises in a range of solid malignancies, including difficult cases with few conventional options.[2]

Misconduct case

In 2020, Stebbing was investigated by the General Medical Council over allegations that he failed to provide adequate care to eleven patients he had cared for between 2014 and 2017.[29][28] The case focused on whether Stebbing had prescribed inappropriate courses of treatment in patients whose cancers were too advanced to benefit from the treatment.[30]

After initially denying all complaints against him, Stebbing eventually admitted 30 of the 36 charges,[30] and was found guilty of another three by a Medical Practitioners Tribunal Service misconduct hearing.[31] A number of Stebbing's patients and their families supported him, saying his "aggressive treatments" brought hope.[30] However, he was found to have inappropriately treated patients given their poor prognosis, overstated benefits of treatment, failed to gain informed consent by not discussing the risks and benefits, and failed to maintain proper records.[28]

The GMG suspended Stebbing from the UK medical register for nine months,[31] with the disciplinary panel finding he had "breached the very core of the Hippocratic oath."[11] However, he was not struck off, after the panel considered mitigating factors and an "unprecedented number" of testimonials to his clinical competence from former patients, family members of patients, and colleagues,[11] finding it in the public interest to allow Stebbing to return to practice "as soon as possible".[31]

Other work

Stebbing has combined his medical career with investing, and he has worked with Atticus Capital, Lansdowne Partners, Vitruvian Partners and Chaired the Board of BB Healthcare Trust.[32] He is senior oncology advisor to Clinical ink,[33] chairs the ZephyrAI scientific advisory board,[34] and is on the boards of Etira[35] and Portage Biotech.[36] He is senior VP of clinical strategy and innovation[37] at Graviton Biosciences focusing on new treatments for fibrosis, inflammation and metabolism based on selective targeting of ROCK2.

References

  1. ^ "Professor Justin Stebbing - ARU". aru.ac.uk. ARU. Retrieved 2022-11-30.
  2. ^ a b "Professor Justin Stebbing". Phoenix Hospital Group. Retrieved 2022-10-29.
  3. ^ "About the Editors | Oncogene". www.nature.com. Retrieved 2022-10-29.
  4. ^ "Home - Professor Justin Stebbing". www.imperial.ac.uk. Retrieved 2022-10-29.
  5. ^ Stebbing, Justin; Gazzard, Brian; Douek, Daniel C. (2004-04-29). "Where Does HIV Live?". New England Journal of Medicine. 350 (18): 1872–1880. doi:10.1056/NEJMra032395. ISSN 0028-4793. PMID 15115833.
  6. ^ Stebbing, J.; Bower, M. (2003). "Redirecting". The Lancet. Oncology. 4 (7): 438–445. doi:10.1016/S1470-2045(03)01142-2. PMID 12850195. Retrieved 2024-01-07.
  7. ^ a b c d e "Profile: Justin Stebbing". Imperial.
  8. ^ "Current NIHR Research Professors". www.nihr.ac.uk. Retrieved 2024-01-07.
  9. ^ "stebbing j - Search Results - PubMed". PubMed. Retrieved 2024-01-07.
  10. ^ "Justin Stebbing". scholar.google.com. Retrieved 2024-01-07.
  11. ^ a b c d Brown, David (20 December 2021). "'Doctor God' Justin Stebbing avoids being struck off for dishonesty after patients rally in support". The Times. Retrieved 23 May 2024.
  12. ^ Leonard, Ian (5 July 2021). "Oncologist Denies Taking on Too Many Patients Leading to Failings". Medscape UK. Retrieved 23 May 2024.
  13. ^ "About the Editors". Oncogene.
  14. ^ "Home | Action Against Cancer". www.aacancer.org. Retrieved 28 March 2023.
  15. ^ Giamas, Georgios; Filipović, Aleksandra; Jacob, Jimmy; Messier, Walter; Zhang, Hua; Yang, Dongyun; Zhang, Wu; Shifa, Belul Assefa; Photiou, Andrew; Tralau-Stewart, Cathy; Castellano, Leandro; Green, Andrew R.; Coombes, R. Charles; Ellis, Ian O.; Ali, Simak; Lenz, Heinz-Josef; Stebbing, Justin (June 2011). "Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer". Nature Medicine. 17 (6): 715–719. doi:10.1038/nm.2351. PMID 21602804. S2CID 5279914.[non-primary source needed]
  16. ^ Castellano, Leandro; Giamas, Georgios; Jacob, Jimmy; Coombes, R. Charles; Lucchesi, Walter; Thiruchelvam, Paul; Barton, Geraint; Jiao, Long R.; Wait, Robin; Waxman, Jonathan; Hannon, Gregory J.; Stebbing, Justin (21 August 2009). "The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response". Proceedings of the National Academy of Sciences. 106 (37): 15732–15737. Bibcode:2009PNAS..10615732C. doi:10.1073/pnas.0906947106. PMC 2747188. PMID 19706389.[non-primary source needed]
  17. ^ Bower, M.; Nelson, M.; Young, A.M.; Thirlwell, C.; Newsom-Davis, T.; Mandalia, S.; Dhillon, T.; Holmes, P.; Gazzard, B.G.; Stebbing, J. (1 August 2005). "Immune Reconstitution Inflammatory Syndrome Associated With Kaposi's Sarcoma". Journal of Clinical Oncology. 23 (22): 5224–5228. doi:10.1200/JCO.2005.14.597. PMID 16051964.[non-primary source needed]
  18. ^ Stebbing, Justin; Baranau, Yauheni; Baryash, Valeriy; Manikhas, Alexey; Moiseyenko, Vladimir; Dzagnidze, Giorgi; Zhavrid, Edvard; Boliukh, Dmytro; Stroyakovskii, Daniil; Pikiel, Joanna; Eniu, Alexandru; Komov, Dmitry; Morar-Bolba, Gabriela; Li, Rubi K.; Rusyn, Andriy; Lee, Sang Joon; Lee, Sung Young; Esteva, Francisco J. (2017). "CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial". The Lancet Oncology. 18 (7): 917–928. doi:10.1016/S1470-2045(17)30434-5. hdl:10044/1/52810. PMID 28592386. Retrieved 2024-01-07.
  19. ^ Stebbing, Justin; Baranau, Yauheni; Baryash, Valery; Moiseyenko, Vladimir; Boliukh, Dmytro; Antone, Nicoleta; Manikhas, Alexey; Chornobai, Anatolii; Park, Taehong; Baek, Eric Hyungseok; Lee, Jaeyong; Choi, Jiin; Kim, Nahyun; Ahn, Keumyoung; Lee, Sang Joon (2023). "Six-Year Survival Outcomes for Patients with HER2-Positive Early Breast Cancer Treated with CT-P6 or Reference Trastuzumab: Observational Follow-Up Study of a Phase 3 Randomised Controlled Trial". Biodrugs. 37 (3): 433–440. doi:10.1007/s40259-023-00582-w. ISSN 1173-8804. PMC 10195725. PMID 36881323.
  20. ^ Richardson, Peter; Griffin, Ivan; Tucker, Catherine; Smith, Dan; Oechsle, Olly; Phelan, Anne; Rawling, Michael; Savory, Edward; Stebbing, Justin (15 February 2020). "Baricitinib as potential treatment for 2019-nCoV acute respiratory disease". The Lancet. 395 (10223): e30 – e31. doi:10.1016/S0140-6736(20)30304-4. PMC 7137985. PMID 32032529.[non-primary source needed]
  21. ^ Stebbing, Justin; Phelan, Anne; Griffin, Ivan; Tucker, Catherine; Oechsle, Olly; Smith, Dan; Richardson, Peter (2020). "COVID-19: combining antiviral and anti-inflammatory treatments". The Lancet Infectious Diseases. 20 (4): 400–402. doi:10.1016/S1473-3099(20)30132-8. PMC 7158903. PMID 32113509.
  22. ^ "Olumiant EUA FAQs | FDA". www.fda.gov. Retrieved 2024-02-14.
  23. ^ Witness to Covid: 2020: The Diary of a Global Pandemic: Amazon.co.uk: Stebbing, Justin, Mukherjee, Siddhartha: 9781398112674: Books. ASIN 1398112674.
  24. ^ Hammond, Terese C.; Purbhoo, Marco A.; Kadel, Sapana; Ritz, Jerome; Nikiforow, Sarah; Daley, Heather; Shaw, Kit; van Besien, Koen; Gomez-Arteaga, Alexandra; Stevens, Don; Ortuzar, Waldo; Michelet, Xavier; Smith, Rachel; Moskowitz, Darrian; Masakayan, Reed (2024-02-06). "A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome". Nature Communications. 15 (1): 974. Bibcode:2024NatCo..15..974H. doi:10.1038/s41467-024-44905-z. ISSN 2041-1723. PMC 10847411. PMID 38321023.
  25. ^ Reporters, Telegraph (2024-02-07). "New cancer drug could improve prognosis for Covid patients". The Telegraph. ISSN 0307-1235. Retrieved 2024-02-14.
  26. ^ Corp, Equilibre Biopharmaceuticals. "Equilibre Biopharmaceuticals Announces Positive Topline Results from Phase 2 Clinical Trial of EQU-001 (NCT05063877) for Safety, Tolerability and Preliminary Efficacy as Adjunctive Therapy for Focal Seizures in Adults with Epilepsy". www.prnewswire.com (Press release). Retrieved 2024-01-07.
  27. ^ "The American Society for Clinical Investigation".
  28. ^ a b c Leonard, Ian. "Leading Oncologist Guilty of Providing Inappropriate Treatment: MPTS". Medscape UK. Retrieved 2022-05-25.
  29. ^ Dyer, Clare (2020-09-15). "Leading oncologist faces GMC allegations of inappropriate treatment of dying patients". BMJ. 370: m3594. doi:10.1136/bmj.m3594. ISSN 1756-1833. PMID 32933903.
  30. ^ a b c Wellesley, Johnna; Tumilty, Emma (13 November 2022). ""Saviour or Sinner?" Why the case of Justin Stebbing matters". British Medical Journal.
  31. ^ a b c Dyer, Clare (2021-12-21). "Oncologist with "cavalier attitude" to treatment is suspended for nine months after patients defend his practice". BMJ. 375: n3130. doi:10.1136/bmj.n3130. ISSN 1756-1833. PMID 34933876.
  32. ^ "BB Healthcare Trust delivers as it comfortably beats its benchmark". Proactiveinvestors UK. 2018-02-14. Retrieved 2024-01-07.
  33. ^ "Justin Stebbing, PhD, M.D. | Expert Advisor". Clinical ink. Retrieved 2024-01-07.
  34. ^ "Zephyr AI Announces Formation of Scientific and Medical Advisory Board". www.businesswire.com. 2022-12-05. Retrieved 2024-01-07.
  35. ^ "Leadership".
  36. ^ "About us".
  37. ^ "Our Company". gravitoncorp.com. Retrieved 2024-02-14.
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