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KDM4D

From Wikipedia, the free encyclopedia
(Redirected from JMJD2D)
KDM4D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM4D, JMJD2D, lysine demethylase 4D
External IDsOMIM: 609766; MGI: 3606484; HomoloGene: 69244; GeneCards: KDM4D; OMA:KDM4D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018039

NM_173433

RefSeq (protein)

NP_060509

NP_775609

Location (UCSC)Chr 11: 94.97 – 95 MbChr 9: 14.37 – 14.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[5][6] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[7][8] A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186280Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053914Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
  6. ^ "Entrez Gene: JMJD2D jumonji domain containing 2D".
  7. ^ Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
  8. ^ Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
  9. ^ Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4): dev158261. doi:10.1242/dev.158261. PMID 29453221.

Further reading

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