Integrin subunit beta like 1

ITGBL1
Identifiers
Aliases	ITGBL1, OSCP, TIED, integrin subunit beta like 1
External IDs	OMIM: 604234; MGI: 2443439; HomoloGene: 3519; GeneCards: ITGBL1; OMA:ITGBL1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q33.1 Start 101,452,593 bp End 101,720,856 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 E5 Start 123,897,383 bp End 124,213,030 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole paraflocculus of cerebellum middle frontal gyrus Descending thoracic aorta ascending aorta Achilles tendon pericardium synovial joint right coronary artery popliteal artery Top expressed in calvaria tunica media of zone of aorta sciatic nerve ascending aorta aortic valve interventricular septum utricle stroma of bone marrow vestibular sensory epithelium skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function integrin binding Cellular component extracellular region plasma membrane focal adhesion integrin complex cell surface Biological process cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell migration cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9358 223272 Ensembl ENSG00000198542 ENSMUSG00000032925 UniProt O95965 Q8VDV0 RefSeq (mRNA) NM_001271754 NM_001271755 NM_001271756 NM_004791 NM_145467 RefSeq (protein) NP_001258683 NP_001258684 NP_001258685 NP_004782 NP_663442 Location (UCSC) Chr 13: 101.45 – 101.72 Mb Chr 14: 123.9 – 124.21 Mb PubMed search
Wikidata
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Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene.

Function

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Further reading

• Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Li XQ, Du X, Li DM, Kong PZ, Sun Y, Liu PF, Wang QS, Feng YM (August 2015). "ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway". Cancer Res. 75 (16): 3302–13. doi:10.1158/0008-5472.CAN-15-0240. PMID 26060017.
• Gan X, Liu Z, Tong B, Zhou J (February 2016). "Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling". Tumour Biol. 37 (2): 1663–9. doi:10.1007/s13277-015-3919-8. PMID 26307393. S2CID 54485581.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.